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Volume 24, Issue 1, Pages 39-50 (February 2010)


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Cretinism revisited

Zu-Pei Chen (Chairman, Regional Coordinator, Former Director)abcCorresponding Author Informationemail address, Basil S. Hetzel, MD, FRCP, FRACP, FFPH, FFAPHM, FTSE (Former Executive Director and then Chairman of the International Council for Control of Iodine Deficiency Disorders (ICCIDD))d1email address

Endemic cretinism includes two syndromes: a more common neurological disorder with brain damage, deaf mutism, squint and spastic paresis of the legs and a less common syndrome of severe hypothyroidism, growth retardation and less severe mental defect.

Both conditions are due to dietary iodine deficiency and can be prevented by correction of iodine deficiency before pregnancy.

Endemic cretinism is now included in the spectrum of the effects of iodine deficiency in a population termed the ‘iodine deficiency disorders (IDDs)’, which also includes a wide range of lesser degrees of cognitive defect that can be prevented by the correction of iodine deficiency.

Iodine deficiency is now recognised by the World Health Organization (WHO) as the most common preventable cause of brain damage with in excess of 2 billion at risk from 130 countries.

A global United Nations (UN) programme of prevention has achieved 68% household usage of iodised salt by the year 2000 compared with less than 20% prior to 1990.

a National IDD Advisory Committee to Ministry of Health, P. R. China

b China and Eastern Asia Region, ICCIDD, P. R. China

c The Institute of Endocrinology, Tianjin Medical University, No. 22 Qixiantai Road, Heping District, Tianjin 300070, P. R. China

d Michell Building, Women's & Children's Hospital, 72 King William Road, North Adelaide SA 5006, Australia

Corresponding Author InformationCorresponding author. The Institute of Endocrinology, Tianjin Medical University, No. 22 Qixiantai Road, Heping District, Tianjin 300070, P. R. China. Tel./Fax: +86 22 23340048.

1 Tel.: +61 8 8161 7021; Fax: +61 8 8161 7221.

PII: S1521-690X(09)00103-1

doi:10.1016/j.beem.2009.08.014


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