Best Practice & Research Clinical Endocrinology & Metabolism
Volume 24, Issue 1 , Pages 107-115 , February 2010

Iodine excess

  • Hans Bürgi, MD (Chair, Science and Technology Committee, International Council for the Control of Iodine Deficiency Disorders (ICCIDD))

      Affiliations

    • Corresponding Author InformationTel.: +41 79 662 45 10; Fax: +41 32 621 24 35.

References 

  1. Zimmermann MB, Jooste PL, Pandav PS. Iodine deficiency disorders. Lancet. 2008;372:1251–1262
  2. Müssig K. Iodine-induced toxic effects due to seaweed consumption. In:  Preedy VR,  Burrow GN,  Ross Watson R editor. Comprehensive handbook of iodine. Amsterdam: Elsevier; 2009;p. 897–908
  3. Wolff J. Iodide goiter and the pharmacologic effects of excess iodide. The American Journal of Medical Electronics. 1969;47:101–124
  4. Fradkin JE, Wolff J. Iodide-induced thyrotoxicosis. Medicine. 1983;62:1–19
  5. Bürgi H. Effets d'apports iodés inappropriés. In:  Leclère J,  Orgiazzi J,  Rousset B, et al. editor. La Thyroïde. Amsterdam: Elsevier; 2001;p. 233–237
  6. Chopra IC, Hershman JM, Hornabrook RW. Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea. The Journal of Clinical Endocrinology and Metabolism. 1975;40:326–331
  7. Patel YC, Pharoa POD, Hornabrook RW, et al. Serum triiodothyronine, thyroxine and thyroid stimulating hormone in endemic goiter. A comparison of goitrous and non-goitrous subjects in New Guinea. The Journal of Clinical Endocrinology and Metabolism. 1973;37:783–788
  8. Braverman LE, Ingbar SH. Changes in thyroidal function during adaptation to large doses of iodide. The Journal of Clinical Investigation. 1963;42:1216–1231
  9. Wolff J. Transport of iodide and other anions in the thyroid gland. Physiological Reviews. 1964;44:45–90
  10. Eskandari S, Loo DDF, Dai G, et al. Na+/I- Symporter. Mechanism, stochiometry, and specificity. The Journal of Biological Chemistry. 1997;272:27230–27238
  11. Riesco- Eizaguirre G, Santisteban P. A perspective view of sodium iodide symporter research and its clinical implications. European Journal of Clinical Investigation. 2006;155:495–512
  12. Bizhanova A, Kopp P. Minireview: the sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009;150:1084–1090
  13. Kogai T, Sajid-Crockett S, Newmarch LS, et al. Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and in human papillary thyroid cancer cells. The Journal of Endocrinology. 2008;199:243–252
  14. Wolff J, Chaikoff IL. Plasma inorganic iodide as a homeostatic regulator of thyroid function. The Journal of Biological Chemistry. 1948;174:555–564
  15. Raben MS. The paradoxical effects of thiocyanate on the organic binding of iodine by the thyroid in the presence of large amounts of iodide. Endocrinology. 1949;45:296–304
  16. Bürgi H, Radvila A, Kohler H, et al. Effects of pharmacological doses of iodide on the hyperplastic rat thyroid gland. Role of intrathyroidal iodide, thyrotropin and thyroglobulin in the Wolff-Chaikoff phenomenon. Endocrinology. 1974;95:388–396
  17. Eng PHK, Cardona GR, Fang SL, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999;140:3404–3410
  18. Pommier J, Dème D, Nunez J. Effect of iodide concentration on thyroxine synthesis catalyzed by thyroid peroxidase. European Journal of Biochemistry. 1973;37:406–412
  19. Corvilain B, Laurent E, Lecomte M, et al. Role of cyclic adenosine3',5'-monophosphate and the phosphatidylinositol-Ca2+ cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. The Journal of Clinical Endocrinology and Metabolism. 1994;79:152–159
  20. Galton VA, Pitt-Rivers RV. The effect of excessive iodine on the thyroid of the rat. Endocrinology. 1959;64:835–841
  21. Halmi NS. Thyroidal iodide transport. Vitamins and Hormones. 1961;19:133–163
  22. Sherwin TR, Tong W. The action of iodide and TSH on thyroid cells showing a double control system for the iodide pump. Endocrinology. 1974;94:1465–1474
  23. Spitzweg C, Joba W, Morris IC, et al. Regulation of sodium iodide symporter gene expression in FRTL-5 rat thyroid cells. Thyroid. 1999;9:821–830
  24. Eng PH, Cardona PR, Previti MC. Regulation of the thyroid iodide symporter by iodide in FRTL-5 cells. European Journal of Endocrinology. 2001;144:139–144
  25. Philippou G, Koutras DA, Piperingos G, et al. The effect of iodine on thyroid hormone levels in normal persons, in hyperthyroid patients and in hypothyroid patients on thyroxine replacement. Clinical Endocrinology. 1992;36:573–578
  26. Goldsmith RE, Eisele ML. The effect of iodide on the release of thyroid hormone in hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism. 1956;16:130–137
  27. Nagataki S, Shizume K, Nakao K. Effect of iodide on iodine turnover in hyperthyroid subjects. The Journal of Clinical Endocrinology and Metabolism. 1970;30:469–478
  28. Shimizu T, Shishiba T, Shishiba Y. Effect of triiodothyronine or iodide on the thyroidal secretion in vitro: inhibition of TSH- and dibutyryl-cyclic AMP- induced endocytosis. Endocrinologia Japonica. 1975;22:55–60
  29. Van Sande J, Grenier G, Willems C, et al. Inhibition by iodide of the activation of the thyroid cyclic 3',5'-AMP 1975. Endocrinology. 1975;96:781–786
  30. Nagataki S, Shizume K, Nakao K. Effect of chronic graded doses of iodide on thyroid hormone synthesis. Endocrinology. 1966;79:667–674
  31. Studer H, Kohler H, Bürgi H. Iodine deficiency. Section 7, Endocrinology, Thyroid In:  Greer MA,  Solomon DH editor. Handbook of physiol. Vol. III:Berne Hans Huber; 1968;p. 303–328
  32. Wang K, Sun YN, Liu JY, et al. The impact of iodine excess on thyroid hormone synthesis and metabolism in rats. Biological Trace Element Research. 2009;130:72–85
  33. Nagataki S, Shizume K, Nakao K. Release of inorganic iodide from thyroid gland in response to chronic iodide administration. Endocrinology. 1969;85:899–908
  34. Nagataki S, Shizume K, Nakao K. Alterations in intrathyroidal iodine metabolism in response to chronic iodide administration. Endocrinology. 1970;87:1218–1227
  35. Jubiz W, Carlile S, Lagerquist LD. Serum thyrotropin and thyroid hormone levels in humans receiving chronic potassium iodide. The Journal of Clinical Endocrinology and Metabolism. 1977;44:379–382
  36. Namba H, Yamashita S, Kimura H, et al. Evidence of thyroid volume increase in normal subjects receiving iodide. The Journal of Clinical Endocrinology and Metabolism. 1993;76:605–608
  37. Sternthal E, Lipworth L, Stanley B, et al. Suppression of thyroid hormone uptake by various doses of stable iodine. The New England Journal of Medicine. 1980;303:1083–1088
  38. Vagenakis AG, Downs P, Braverman LE, et al. Control of thyroid hormone secretion in normal subjects receiving iodides. The Journal of Clinical Investigation. 1973;52:528–532
  39. Vagenakis AG, Rapoport B, Azizi F, et al. Hyperresponse to thyrotropin-releasing hormone accompanying small decreases in serum thyroid hormone concentration. The Journal of Clinical Investigation. 1974;54:913–918
  40. Braverman LE, Woeber KA, Ingbar SH. Induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of diffuse toxic goiter. The New England Journal of Medicine. 1969;281:816–821
  41. Roti E, Gardini E, Bianconi L, et al. Effects of chronic iodine administration on thyroid status in euthyroid subjects previously treated with antithyroid drugs for Graves' hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism. 1993;76:928–932
  42. Clark OH, Cavalieri RR, Moser C, et al. Iodide-induced hypothyroidism in patients after thyroid resection. European Journal of Clinical Investigation. 1990;20:573–580
  43. Braverman LE, Ingbar SH, Vagenakis AG, et al. Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. The Journal of Clinical Endocrinology and Metabolism. 1971;32:515–521
  44. Roti E, Minelli R, Gardint E, et al. Impaired intrathyroidal iodine organification and iodine-induced hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis. The Journal of Clinical Endocrinology and Metabolism. 1991;73:958–963
  45. Chow CC, Phillips DIW, Lazarus JH, et al. Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable?. Clinical Endocrinology. 1991;34:413–416
  46. Reinhardt W, Luster M, Rudorff KH, et al. Effect of small doses of iodine in patients with Hashimoto's thyroiditis residing in an area of mild iodine deficiency. European Journal of Endocrinology. 1991;139:23–28
  47. Bürgi H, Supersaxo Z, Selz B. Iodine deficiency diseases in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goitre prevalence data. Acta Endocrinologica. 1990;123:577–590
  48. Todd CH, Allain T, Gomo ZAR, et al. Increase in thyrotoxicosis associated with iodine supplements in Simbabwe. Lancet. 1995;346:1563–1564
  49. Bourdoux P, Erman AM, Mukalay WA, et al. Iodine induced thyrotoxicosis in Kiwu Zaire. Lancet. 1996;347:552–553
  50. Ermans AM, Camus M. Modification of thyroid function induced by chronic administration of iodide in the presence of “autonomous” thyroid tissue. Acta Endocrinologica. 1972;70:463–475
  51. Corvilain B, Van Sande J, Dumont JE, et al. Autonomy in endemic goiter. Thyroid. 1998;8:107–113
  52. Parma J, Duprez L, Van Sande J. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature. 1993;365:649–651
  53. Bürgi H, Kohler M, Morselli B. Thyrotoxicosis incidence in Switzerland and benefit of improved iodine supply. Lancet. 1998;352:1034
  54. Lewinski A, Zygmunt A, Karbownik-Lewinska M, et al. Detrimental effects of increasing iodine supply: iodine-induced hyperthyroidism, following iodine prophylaxis. In:  Preedy VR,  Burrow GN,  Ross Watson R editor. Comprehensive handbook of iodine. Amsterdam: Elsevier; 2009;p. 871–875
  55. Vagenakis AG, Wang CA, Burger A, et al. Iodide-induced thyrotoxicosis in Boston. The New England Journal of Medicine. 1972;287:523–527
  56. Bülow Pedersen I, Laurberg P, Knudsen N, et al. Increase in incidence of hyperthyroidism predominantly occurs in young people after iodine fortification of salt in Denmark. The Journal of Clinical Endocrinology and Metabolism. 2006;91:3830–3834
  57. Savoie GC, Massin JP, Thomopoulos P, et al. Iodine-induced thyrotoxicosis in apparently normal thyroid glands. The Journal of Clinical Endocrinology and Metabolism. 1975;41:685–691
  58. Léger A, Massin JP, Laurent MF, et al. Iodine-induced thyrotoxicosis: analysis of 85 consecutive cases. European Journal of Clinical Investigation. 1984;14:449–455
  59. Teng W, Shan Z, Teng X, et al. Effect of iodine intake on thyroid diseases in China. The New England Journal of Medicine. 2006;354:2783–2793
  60. Yang F, Shan Z, Chen Y, et al. Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China. European Journal of Endocrinology. 2007;156:403–408
  61. Teng WP, Shan Z, Teng X. Effects of an increased iodine intake on thyroid diseases: epidemiological study from China. In:  Preedy VR,  Burrow GN,  Ross Watson R editor. Comprehensive handbook of iodine. Amsterdam: Elsevier; 2009;p. 1213–1220
  62. Baltensberger BL, Minder C, Bürgi H. Decrease of incidence of toxic nodular goitre in a region of Switzerland after full correction of mild iodine deficiency. European Journal of Endocrinology. 1995;546:546–549
  63. Teng X, Shan Z, Teng W, et al. Experimental study on the effects of chronic iodine excess on thyroid function, structure, and autoimmunity in autoimmune-prone NOD.H-2h4 mice. Clinical and Experimental Medicine. 2009;9:51–59
  64. Emral R, Bastemir M, Erdogan G, et al. High prevalence thyroid dysfunction and autoimmune thyroiditis in adolescents after elimination of iodine deficiency in eastern Black Sea region of Turkey. Turkish Journal of Endocrinology and Metabolism. 2006;1:13–20
  65. Zimmermann MB, Moretti D, Chaouki N, et al. Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: a one-year prospective trial in northern Morocco. Thyroid. 2003;13:199–203
  66. Trip MD, Wiersinga W. Incidence, predictability and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism. The American Journal of Medical Electronics. 1991;91:507–511
  67. Bakker A, Wiersinga W. Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone β1-receptor protein. Endocrinology. 1994;134:1665–1670
  68. DeGroot LJ, Rue PA. Roentgenographic contrast agents inhibit triiodothyronine binding to nuclear receptors in vitro. The Journal of Clinical Endocrinology and Metabolism. 1979;49:538–542
  69. Basaria S, Cooper DS. Amiodarone and the thyroid. The American Journal of Medicine. 2005;118:706–714
  70. Roti E, degli Uberti E. Iodine excess and hyperthyroidism. Thyroid. 2001;11:493–500

PII: S1521-690X(09)00102-X

doi: 10.1016/j.beem.2009.08.010

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 24, Issue 1 , Pages 107-115 , February 2010

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