Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 5 , Pages 597-606 , October 2009

TSH-secreting adenomas

  • Paolo Beck-Peccoz, MD

      Affiliations

    • Department of Medical Sciences, University of Milan, Fondazione Policlinico IRCCS, Padiglione Granelli, Via F. Sforza 35, 20122 Milan, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 02 50320606, 607; Fax: +39 02 50320605.
  • ,
  • Luca Persani, MD, PhD

      Affiliations

    • Istituto Auxologico Italiano IRCCS, Via Zucchi 18, 20095 Cusano Milanino, Italy
  • ,
  • Deborah Mannavola, MD, PhD

      Affiliations

    • Department of Medical Sciences, University of Milan, Fondazione Policlinico IRCCS, Padiglione Granelli, Via F. Sforza 35, 20122 Milan, Italy
  • ,
  • Irene Campi, MD

      Affiliations

    • Department of Medical Sciences, University of Milan, Fondazione Policlinico IRCCS, Padiglione Granelli, Via F. Sforza 35, 20122 Milan, Italy

References 

  1. Beck-Peccoz P, Brucker-Davis F, Persani L, et al. Thyrotropin-secreting pituitary tumors. Endocrine Reviews. 1996;17:610–638
  2. Beck-Peccoz P, Persani L. TSH-producing adenomas. In:  DeGroot LJ,  Jameson JL editor. Endocrinology. 5th edn.. Philadelphia: Elsevier Saundres; 2006;p. 475–484
  3. Refetoff S, Weiss RE, Usala SJ. The syndromes of resistance to thyroid hormone. Endocrine Reviews. 1993;14:348–399
  4. Gurnell M, Beck-Peccoz P, Chatterjee VK. Resistance to thyroid hormone. In:  DeGroot LJ,  Jameson JL editor. Endocrinology. 5th edn.. Philadelphia: Elsevier Saundres; 2006;p. 2227–2237
  5. Kienitz T, Quinkler M, Strasburger CJ, et al. Long-term management in five cases of TSH-secreting pituitary adenomas: a single center study and review of the literature. European Journal of Endocrinology. 2007;157:39–46
  6. Ness-Abramof R, Ishay A, Harel G, et al. TSH-secreting pituitary adenomas. Pituitary. 2007;10:307–310
  7. Foppiani L, Del Monte P, Ruelle A, et al. TSH-secreting adenomas: rare pituitary tumors with multifaceted clinical and biological features. Journal of Endocrinological Investigation. 2007;30:603–609
  8. Clarke MJ, Erickson D, Castro MR, et al. Thyroid-stimulating pituitary adenomas. Journal of Neurosurgery. 2008;109:17–22
  9. Gershengorn MC, Weintraub BD. Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of “inappropriate secretion of TSH”. The Journal of Clinical Investigation. 1975;56:633–642
  10. Mixson AJ, Friedman TC, David AK, et al. Thyrotropin-secreting pituitary carcinoma. The Journal of Clinical Endocrinology and Metabolism. 1993;76:529–533
  11. Brown RL, Muzzafar T, Wollman R, et al. A pituitary carcinoma secreting TSH and prolactin: a non-secreting adenoma gone awry. European Journal of Endocrinology. 2006;154:639–643
  12. Cohen LE, Radovick S. Molecular bases of pituitary hormone deficiencies. Endocrine Reviews. 2002;23:431–442
  13. Mantovani G, Asteria C, Pellegrini C, et al. HESX1 expression in human normal pituitaries and pituitary adenomas. Molecular and Cellular Endocrinology. 2006;247:135–139
  14. Ma W, Ikeda H, Watabe N, et al. A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. Hormone Research. 2003;59:257–261
  15. Dong Q, Brucker-Davis F, Weintraub BD, et al. Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the Gαq, Gα11, Gαs, or thyrotropin-releasing hormone receptor genes. The Journal of Clinical Endocrinology and Metabolism. 1996;81:1134–1140
  16. Asteria C, Anagni M, Persani L, et al. Loss of heterozigosity of the MEN1 gene in a large series of TSH-secreting pituitary adenomas. Journal of Endocrinological Investigation. 2001;24:796–801
  17. Ando S, Sarlis NJ, Krishnan J, et al. Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Molecular Endocrinology. 2001;15:1529–1538
  18. Ando S, Sarlis NJ, Oldfield EH, et al. Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor. The Journal of Clinical Endocrinology and Metabolism. 2001;86:5572–5576
  19. Lu C, Willingham MC, Furuya F, et al. Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyrois-stimulating hormone-secreting pituitary tumors. Endocrinology. 2008;149:3339–3345
  20. Horiguchi K, Yamada M, Umezawa R, et al. Somatostatin receptor subtypes mRNA in TSH-secreting pituitary adenomas: a case showing a dramatic reduction in tumor size during short octreotide treatment. Endocrine Journal. 2007;54:371–378
  21. Filopanti M, Ballaré E, Lania AG, et al. Loss of heterozygosity at the SS receptor type 5 locus in human GH- and TSH-secreting pituitary adenomas. Journal of Endocrinological Investigation. 2004;27:937–942
  22. Ezzat S, Horvath E, Kovacs K, et al. Basic fibroblast growth factor expression by two prolactin and thyrotropin-producing pituitary adenomas. Endocrine Pathology. 1995;6:125–134
  23. Brucker-Davis F, Oldfield EH, Skarulis MC, et al. Thyrotropin-secreting pituitary tumors: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the National Institutes of Health. The Journal of Clinical Endocrinology and Metabolism. 1999;84:476–486
  24. Langlois MF, Lamarche JB, Bellabarba D. Long-standing goiter and hypothyroidism: an unusual presentation of a TSH-secreting adenoma. Thyroid. 1996;6:329–335
  25. Idiculla JM, Beckett G, Statham PFX, et al. Autoimmune hypothyroidism coexisting with a pituitary adenoma secreting thyroid-stimulating hormone, prolactin and α-subunit. Annals of Clinical Biochemistry. 2001;38:566–571
  26. Losa M, Mortini P, Minelli R, et al. Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism. Journal of Endocrinological Investigation. 2006;29:555–559
  27. Gasparoni P, Rubello D, Persani L, et al. Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma. Thyroid. 1998;8:181–183
  28. Ohta S, Nishizawa S, Oki Y, et al. Coexistence of thyrotropin-producing pituitary adenoma with papillary adenocarcinoma of the thyroid: a case report and surgical strategy. Pituitary. 2001;4:271–274
  29. Abs R, Stevenaert A, Beckers A. Autonomously functioning thyroid nodules in a patient with a thyrotropin-secreting pituitary adenoma: possible cause-effect relationship. European Journal of Endocrinology. 1994;131:355–358
  30. Kourides IA, Pekonen F, Weintraub BD. Absence of thyroid-binding immunoglobulins in patients with thyrotropin-mediated hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism. 1980;51:272–274
  31. Socin HV, Chanson P, Delemer B, et al. The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. European Journal of Endocrinology. 2003;148:433–442
  32. Terzolo M, Orlandi F, Bassetti M, et al. Hyperthyroidism due to a pituitary adenoma composed of two different cell types, one secreting alpha-subunit alone and another cosecreting alpha-subunit and thyrotropin. The Journal of Clinical Endocrinology and Metabolism. 1991;72:415–421
  33. Persani L, Preziati D, Matthews CH, et al. Serum levels of carboxyterminal cross-linked telopeptide of type I collagen (ICTP) in the differential diagnosis of the syndromes of inappropriate secretion of TSH. Clinical Endocrinology. 1997;47:207–214
  34. Bertherat J, Brue T, Enjalbert A, et al. Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions. The Journal of Clinical Endocrinology and Metabolism. 1992;75:540–546
  35. Gancel A, Vuillermet P, Legrand A, et al. Effets of a slow-release formulation of the new somatostatin analogue lanreotide in TSH-secreting pituitary adenomas. Clinical Endocrinology. 1994;40:421–428
  36. Chanson P, Weintraub BD, Harris AG. Octreotide therapy for thyroid stimulating-secreting pituitary adenomas. A follow-up of 52 patients. Annals of Internal Medicine. 1993;119:236–240
  37. Kuhn JM, Arlot S, Lefebvre H, et al. Evaluation of the treatment of thyrotropin-secreting pituitary adenomas with a slow release formulation of the somatostatin analog lanreotide. The Journal of Clinical Endocrinology and Metabolism. 2000;85:1487–1491
  38. Mannavola D, Persani L, Vannucchi G, et al. Different response to chronic somatostatin analogues in patients with central hyperthyroidism. Clinical Endocrinology. 2005;62:176–181
  39. Losa M, Magnani P, Mortini P, et al. Indium-111 pentetreotide single-photon emission tomography in patients with TSH-secreting pituitary adenomas: correlation with the effect of a single administration of octreotide on serum TSH levels. European Journal of Nuclear Medicine. 1997;24:728–731
  40. Cooper DS, Wenig BM. Hyperthyroidism caused by an ectopic TSH-secreting pituitary tumor. Thyroid. 1996;6:337–343
  41. Pasquini E, Faustini-Fustini M, Sciarretta V, et al. Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. European Journal of Endocrinology. 2003;148:253–257
  42. Webster J, Peters JR, John R, et al. Pituitary stone: two cases of densely calcified thyrotropin-secreting pituitary adenomas. Clinical Endocrinology. 1994;40:137–143
  43. Losa M, Giovanelli M, Persani L, et al. Criteria of cure and follow-up of central hyperthyroidism due to thyrotropin-secreting pituitary adenomas. The Journal of Clinical Endocrinology and Metabolism. 1996;81:3086–3090
  44. Ohki M, Sato K, Tuchiya D, et al. A case of TSH-secreting pituitary adenoma associated with an unruptured aneurysm: successful treatment by two-stage operation and gamma knife. No To Shinkei. 1999;51:895–899
  45. Rocheville M, Lange DC, Kumar U, et al. Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science. 2000;288:154–157
  46. Blackhurst G, Strachan MW, Collie D, et al. The treatment of a thyrotropin-secreting pituitary macroadenoma with octreotide in twin pregnancy. Clinical Endocrinology. 2002;57:401–404
  47. Chaiamnuay S, Moster M, Katz MR, et al. Successful management of a pregnant woman with a TSH secreting pituitary adenoma with surgical and medical therapy. Pituitary. 2003;6:109–113

PII: S1521-690X(09)00052-9

doi: 10.1016/j.beem.2009.05.006

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 5 , Pages 597-606 , October 2009