« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 4
, Pages 487-498
, August 2009
Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin – diabetes control and potential adverse events
References
- Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trials. Current Medical Research and Opinion. 2008;24:489–496
- . Vildagliptin: novel pharmacological approach to treat type 2 diabetes. Therapy. 2008;5:79–90
- Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Journal of Medicinal Chemistry. 2006;48:5025–5037
- . The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–1705
- . Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes. Bioessays. 1998;20:642–651
- . Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia. 2005;48:1700–1713
- . The role of GLP-1 in the life and death of pancreatic beta cells. Hormone and Metabolic Research. 2004;36:804–810
- Effects of glucagon-like peptide-1 in patients with myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation. 2004;109:962–965
- Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. The American Journal of Physiology. 2004;287:E1209–E1215
- . Exenatide: a novel treatment of type 2 diabetes. Therapy. 2005;2:207–222
- . DPP-4 inhibitors. Best Practice & Research. Clinical Endocrinology & Metabolism. 2007;21:517–533
- . Dipeptidyl peptidase-4 inhibitors: clinical data and clinical implications. Diabetes Care. 2007;30:1344–1350
- . GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Hormone and Metabolic Research. 2004;36:867–876
- . Dipeptidyl-peptidase IV (CD26) – role in the inactivation of regulatory peptides. Regulatory Peptides. 1999;85:9–24
- Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care. 2007;30:1862–1864
- Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 2004;89:2078–2084
- Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 2005;90:4888–4894
- Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care. 2005;28:1936–1940
- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49:2564–2571
- Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. Hormone and Metabolic Research. 2007;39:826–829
- The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single dose administration in type 2 diabetic patients. The Journal of Clinical Endocrinology and Metabolism. 2007;92:12249–12255
- Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4 week study period in type 2 diabetes. Diabetes Care. 2002;25:869–875
- Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes, Obesity & Metabolism. 2007;9:186–193
- Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β-cell mass and function in a rodent model of type 2 diabetes. Diabetes. 2006;55:1695–1704
- DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell specific overexpression of human islet amyloid polypeptide. Regulatory Peptides. 2007;143:97–103
- Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 2008;93:459–464
- Improved glucaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. Diabetes, Obesity & Metabolism. 2005;7:692–698
- Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Hormone and Metabolic Research. 2006;387:423–438
- Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Research and Clinical Practice. 2007;76:132–138
- Vildagliptin in drug-naïve patients with type 2 diabetes: a 24 week double-blind, randomized, placebo-controlled, multiple-dose study. Hormone and Metabolic Research. 2007;39:218–223
- Scherbaum WA, Schweizer A, Mari A etal. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia. Diabetes, Obesity & Metabolism 2008; 10: 1114–1124.
- Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care. 2008;31:30–35
- Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Current Medical Research and Opinion. 2007;23:1329–1339
- Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. International Journal of Clinical Practice. 2007;61:171–180
- Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29:2632–2637
- . Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naïve patients with type 2 diabetes. Diabetes, Obesity & Metabolism. 2008;10:376–386
- Once-daily saxagliptin monotherapy improves glycemic control in drug-naïve patients with type 2 diabetes. Diabetes. 2008;57(suppl. 1):A154
- Management of type 2 diabetes in treatment-naïve elderly patients: benefits and risks of vildagliptin monotherapy. Diabetes Care. 2007;30:3017–3022
- Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care. 2007;30:217–223
- Comparison between vildagliptin and metformin to sustain reductions in HbA1c over 1 year in drug-naïve patients with type 2 diabetes. Diabetic Medicine. 2007;24:955–961
- Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2874–2880
- Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care. 2007;30:890–895
- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29:2638–2643
- Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care. 2007;30:1979–1987
- Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week randomized, double-blind study. Diabetes, Obesity & Metabolism. 2008;10:82–90
- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes, Obesity & Metabolism. 2007;9:194–205
- Scott R, Loeys T, Davies M.J et al. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes, Obesity & Metabolism 2008; 10: 959–969.
- Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes, Obesity & Metabolism. 2007;9:166–174
- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clinical Therapy. 2006;28:1556–1568
- Garber A.J, Foley J.E, Banerji M.A etal. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes, Obesity & Metabolism 2008; 10: 1047–1056.
- Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes, Obesity & Metabolism. 2007;9:733–745
- Addition of vildagliptin to insulin improves glycemic control in type 2 diabetes. Diabetologia. 2007;50:1148–1155
- Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia. 2006;49:2049–2057
- . Vildagliptin significantly decreases blood pressure in hypertensive patients with type 2 diabetes compared with metformin. Diabetes. 2007;56(suppl. 1):A139
- Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Research and Clinical Practice. 2007;76:132–138
- Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes. Journal of Clinical Endocrinology & Metabolism. 2009;94:1236–1243
- . New Galvus clinical data reinforces efficacy profile; safety update provided to regulatory agencies. Press Release. November 6, 2009;
- Safety and efficacy of sitagliptin in patients with type 2 diabetes and chronic renal insufficiency. Diabetes, Obesity & Metabolism. 2008;10:545–555
- Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9. Diabetes. 2005;54:2988–2994
- Burkey B.F, Hoffman P.K, Hassiepen U et-al. Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited. Diabetes, Obesity & Metabolism 2008; 10: 1057–1061.
- Sitagliptin, a selective DPP-4 inhibitor, and metformin have complimentary effects to increase active GLP-1 concentrations. Diabetologia. 2008;50(suppl. 1):S52
- The dipeptidyl peptidase-4 inhibitor vildagliptin increases portal concentrations of active GLP-1 to a greater extent than the peripheral concentration. Diabetes. 2008;57(suppl. 1):A411
- Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat. Biochemical and Biophysical Research Communications. 2007;362:1007–1012
- . Inhibition of DPP-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice. Endocrinology. 2005;146:2055–2059
PII: S1521-690X(09)00022-0
doi: 10.1016/j.beem.2009.03.003
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 4
, Pages 487-498
, August 2009
