Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 1 , Pages 79-86 , February 2009

The role of the endocannabinoid system in the regulation of energy expenditure

  • Paul Cavuoto, BSc (Biomedical), BHthSc (Hon)
  • ,
  • Gary A. Wittert, MBBch, MD, FRACP (Professor)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +61 8 8222 5502; Fax: +61 8 8222 3870.

References 

  1. Cota D, Marsicano G, Tschop M, et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. Journal of Clinical Investigation. 2003;112(3):423–431
  2. Ravinet Trillou C, Delgorge C, Menet C, et al. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity and Related Metabolic Disorders. 2004;28(4):640–648
  3. Kunz I, Meier MK, Bourson A, et al. Effects of rimonabant, a cannabinoid CB1 receptor ligand, on energy expenditure in lean rats. International Journal of Obesity (London). 2008;32(5):863–870
  4. Herling AW, Kilp S, Elvert R, et al. Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats. Endocrinology. 2008;149(5):2557–2566
  5. Bensaid M, Gary-Bobo M, Esclangon A, et al. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Molecular Pharmacology. 2003;63(4):908–914
  6. Osei-Hyiaman D, DePetrillo M, Pacher P, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. Journal of Clinical Investigation. 2005;115(5):1298–1305
  7. Matias I, Gonthier MP, Orlando P, et al. Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and {beta}-Pancreatic Cells and in Obesity and Hyperglycemia. Journal of Clinical Endocrinology and Metabolism. 2006;91(8):3171–3180
  8. Pagotto U, Marsicano G, Cota D, et al. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine Reviews. 2006;27(1):73–100
  9. Pertwee RG. Cannabinoids and the gastrointestinal tract. Gut. 2001;48(6):859–867
  10. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395(6704):763–770
  11. Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 2001;410(6830):822–825
  12. Jo YH, Chen YJ, Chua SC, et al. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron. 2005;48(6):1055–1066
  13. Preston E, Triandafillou J, Haas N. Colchicine lesions of ventromedial hypothalamus: effects on regulatory thermogenesis in the rat. Pharmacology, Biochemistry, and Behavior. 1989;32(1):301–307
  14. Bingham NC, Anderson KK, Reuter AL, et al. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology. 2008;149(5):2138–2148
  15. Dhillon H, Zigman JM, Ye C, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191–203
  16. Esfandyari T, Camilleri M, Ferber I, et al. Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study. Neurogastroenterology and Motility. 2006;18(9):831–838
  17. Coutts AA, Pertwee RG. Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus–longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP. Canadian Journal of Physiology and Pharmacology. 1998;76(3):340–346
  18. Izzo AA, Mascolo N, Pinto L, et al. The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats. European Journal of Pharmacology. 1999;384(1):37–42
  19. Di Marzo V, Capasso R, Matias I, et al. The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet. British Journal of Pharmacology. 2008;153(6):1272–1280
  20. Gomez R, Navarro M, Ferrer B, et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. Journal of Neuroscience. 2002;22(21):9612–9617
  21. Yuece B, Sibaev A, Broedl UC, et al. Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex. Neurogastroenterology and Motility. 2007;19(9):744–753
  22. Gary-Bobo M, Elachouri G, Gallas JF, et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology. 2007;46(1):122–129
  23. Nakata M, Yada T. Cannabinoids inhibit insulin secretion and cytosolic Ca(2+) oscillation in islet beta-cells via CB1 receptors. Regulatory Peptides. 2008;145:49–53
  24. Starowicz KM, Cristino L, Matias I, et al. Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. Obesity (Silver Spring). 2008;16(3):553–565
  25. Juan-Pico P, Fuentes E, Bermudez-Silva FJ, et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. Cell Calcium. 2006;39(2):155–162
  26. Bermudez-Silva FJ, Sanchez-Vera I, Suarez J, et al. Role of cannabinoid CB2 receptors in glucose homeostasis in rats. European Journal of Pharmacology. 2007;565(1–3):207–211
  27. Tharp WG, Lee YH, Maple R, et al. The cannabinoid CB1 receptor is expressed in pancreatic delta-cells. Biochemical and Biophysical Research Communications. 2008;372(4):595–600
  28. Yan ZC, Liu DY, Zhang LL, et al. Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-delta. Biochemical and Biophysical Research Communications. 2007;354(2):427–433
  29. Jbilo O, Ravinet-Trillou C, Arnone M, et al. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB Journal. 2005;19(11):1567–1569
  30. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine. 2002;8(11):1288–1295
  31. Lihn AS, Jessen N, Pedersen SB, et al. AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Biochemical and Biophysical Research Communications. 2004;316(3):853–858
  32. Kola B, Hubina E, Tucci SA, et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. Journal of Biological Chemistry. 2005;280(26):25196–25201
  33. Motaghedi R, McGraw TE. The CB1 Endocannabinoid System Modulates Adipocyte Insulin Sensitivity. Obesity (Silver Spring). 2008;16(8):1727–1734
  34. Kempf K, Hector J, Strate T, et al. Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. Hormone and Metabolic Research. 2007;39(8):596–600
  35. Tedesco L, Valerio A, Cervino C, et al. Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through eNOS expression in white adipocytes. Diabetes. 2008;57(8):2028–2036
  36. Zhou D, Shearman LP. Voluntary exercise augments acute effects of CB1-receptor inverse agonist on body weight loss in obese and lean mice. Pharmacology, Biochemistry, and Behavior. 2004;77(1):117–125
  37. Roche R, Hoareau L, Bes-Houtmann S, et al. Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes. Histochemistry and Cell Biology. 2006;126:177–187
  38. Zurlo F, Larson K, Bogardus C, et al. Skeletal muscle metabolism is a major determinant of resting energy expenditure. Journal of Clinical Investigation. 1990;86(5):1423–1427
  39. Cavuoto P, McAinch AJ, Hatzinikolas G, et al. The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and Biophysical Research Communications. 2007;364(1):105–110
  40. Liu YL, Connoley IP, Wilson CA, et al. Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. International Journal of Obesity and Related Metabolic Disorders. 2005;29(2):183–187
  41. Cavuoto P, McAinch AJ, Hatzinikolas G, et al. Effects of Cannabinoid Receptors on Skeletal Muscle Oxidative Pathways. Molecular and Cellular Endocrinology. 2007;267(1-2):63–69
  42. Newman Z, Malik P, Wu TY, et al. Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction. European Journal of Neuroscience. 2007;25(6):1619–1630
  43. Matias I, Petrosino S, Racioppi A, et al. Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: effect of high fat diets. Molecular and Cellular Endocrinology. 2008;286;[Note(s): S66–S78]
  44. Engeli S, Bohnke J, Feldpausch M, et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes. 2005;54(10):2838–2843
  45. Evans DJ, Murray R, Kissebah AH. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. Journal of Clinical Investigation. 1984;74(4):1515–1525
  46. Lonnqvist F, Nordfors L, Jansson M, et al. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. Journal of Clinical Investigation. 1997;99(10):2398–2404
  47. Kelley DE, Goodpaster B, Wing RR, et al. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. American Journal of Physiology. Endocrinology and Metabolism. 1999;277(6 Pt 1):1130–1141
  48. D'Eon TM, Pierce KA, Roix JJ, et al. The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids. Diabetes. 2008;57(5):1262–1268
  49. Buettner C, Muse ED, Cheng A, et al. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nature Medicine. 2008;14(6):667–675

PII: S1521-690X(08)00138-3

doi: 10.1016/j.beem.2008.10.005

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 1 , Pages 79-86 , February 2009