« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 1
, Pages 51-63
, February 2009
The role of the endocannabinoid system in lipogenesis and fatty acid metabolism
References
- Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. Apr 12 2001;410(6830):822–825
- Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. Dec 18 1992;258(5090):1946–1949
- The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine Reviews. Feb 2006;27(1):73–100
- Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. Aug 9 1990;346(6284):561–564
- . Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. British Journal of Pharmacology. Nov 2007;152(5):576–582
- The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms. The Journal of Clinical Endocrinology and Metabolism. Dec 2007;92(12):4810–4819
- Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. The Journal of Clinical Investigation. May 2005;115(5):1298–1305
- Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Developmental Cell. Jul 2002;3(1):25–38
- The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. The Journal of Clinical Investigation. Aug 2003;112(3):423–431
- Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. Apr 16–22 2005;365(9468):1389–1397
- Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA: the Journal of the American Medical Association. Feb 15 2006;295(7):761–775
- Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet. Nov 11 2006;368(9548):1660–1672
- . Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. The New England Journal of Medicine. Nov 17 2005;353(20):2121–2134
- Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. The Journal of Clinical Endocrinology and Metabolism. Aug 2006;91(8):3171–3180
- The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Molecular Pharmacology. Apr 2003;63(4):908–914
- . Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology. Feb 21 2003;462(1–3):125–132
- Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes. Histochemistry and Cell Biology. Aug 2006;126(2):177–187
- Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. Biochimie. Dec 2006;88(12):1889–1897
- Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. Nov 2006;55(11):3053–3060
- CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity and Related Metabolic Disorders. Apr 2004;28(4):640–648
- Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. American Journal of Physiology Regulatory Integrative and Comparative Physiology. Feb 2003;284(2):R345–R353
- The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. The FASEB Journal. Sep 2005;19(11):1567–1569
- Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats. Endocrinology. May 2008;149(5):2557–2566
- Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. The Journal of Clinical Investigation. Nov 2004;114(9):1281–1289
- Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. The Journal of Clinical Endocrinology and Metabolism. Dec 2005;90(12):6650–6656
- Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes. May 2005;54(5):1392–1399
- Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes. Aug 2008;57(8):2028–2036
- . Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews. Dec 2006;27(7):728–735
- . Effect of delta9-tetrahydrocannabinol on mitochondrial NADH-oxidase activity. The Journal of Biological Chemistry. Aug 25 1976;251(16):5002–5006
- Identification of endocannabinoids and related compounds in human fat cells. Obesity (Silver Spring, Md.). Apr 2007;15(4):837–845
- Activation of the peripheral endocannabinoid system in human obesity. Diabetes. Oct 2005;54(10):2838–2843
- Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science. Feb 7 2003;299(5608):896–899
- Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science. Oct 14 2005;310(5746):314–317
- Endocannabinoids in adipocytes during differentiation and their role in glucose uptake. Cellular and Molecular Life Sciences. Jan 2007;64(2):219–229
- Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. The Journal of Biological Chemistry. Jul 1 2005;280(26):25196–25201
- Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nature Medicine. Jun 2008;14(6):667–675
- Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. International Journal of Obesity. Feb 2005;29(2):183–187
- Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level. The Journal of Clinical Endocrinology and Metabolism. Apr 2007;92(4):1555–1559
- Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity. Hormone and Metabolic Research. Aug 2007;39(8):596–600
- . The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. Feb 2004;53(Suppl. 1):S43–S50
- PPARs, Obesity, and Inflammation. PPAR Research. 2007;2007:95974
- . Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience. 2004;123(1):131–145
- Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons. Neuroscience. 2005;130(2):325–337
- Cannabinoids and PPARalpha signalling. Biochemical Society Transactions. Dec 2006;34(Pt 6):1095–1097
- 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. The Journal of Biological Chemistry. Jun 28 2002;277(26):23278–23286
- Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. Molecular Pharmacology. May 2003;63(5):983–992
- Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Molecular Pharmacology. Jul 2006;70(1):101–111
- Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma. Biochemical and Biophysical Research Communications. Nov 25 2005;337(3):824–831
- Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation. European Journal of Pharmacology. Jul 11 2005;517(3):174–181
- Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proceedings of the National Academy of Sciences of the United States of America. Apr 29 1997;94(9):4318–4323
- Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: effect of high fat diets. Molecular and Cellular Endocrinology. Apr 16 2008;286(1–2 Suppl. 1):S66–S78
- Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. Sep 4 2003;425(6953):90–93
- Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). The Journal of Biological Chemistry. Jul 2 2004;279(27):27849–27854
- Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. The Journal of Pharmacology and Experimental Therapeutics. Dec 2006;319(3):1051–1061
- . PPAR delta: a dagger in the heart of the metabolic syndrome. The Journal of Clinical Investigation. Mar 2006;116(3):590–597
- Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-delta. Biochemical and Biophysical Research Communications. Mar 9 2007;354(2):427–433
- The role of adipocyte insulin resistance in the pathogenesis of obesity-related elevations in endocannabinoids. Diabetes. May 2008;57(5):1262–1268
- Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals. Journal of Endocrinological Investigation. Sep 2007;30(8):RC17–RC21
- Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. Obesity (Silver Spring, Md.). Mar 2008;16(3):553–565
- Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa. Neuropsychopharmacology. Jun 2005;30(6):1216–1221
- Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. International Journal of Obesity. Apr 2007;31(4):692–699
- . The endocannabinoid system in obesity and type 2 diabetes. Diabetologia. Aug 2008;51(8):1356–1367
- . Endocannabinoids, adipose tissue and lipid metabolism. Journal of Neuroendocrinology. May 2008;20(Suppl. 1):124–129
- A brain-liver circuit regulates glucose homeostasis. Cell Metabolism. Jan 2005;1(1):53–61
- Critical role of STAT3 in leptin's metabolic actions. Cell Metabolism. Jul 2006;4(1):49–60
- Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. The Journal of Clinical Investigation. Feb 2004;113(3):414–424
- Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science. Jun 16 2006;312(5780):1656–1659
- Hepatic CB(1) receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. The Journal of Clinical Investigation. Aug 1 2008;
- Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats. Journal of Neuroendocrinology. May 2008;20(Suppl. 1):116–123
- Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor. European Journal of Pharmacology. Apr 28 2008;584(2–3):338–342
- Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. JAMA: the Journal of the American Medical Association. Apr 2 2008;299(13):1547–1560
PII: S1521-690X(08)00120-6
doi: 10.1016/j.beem.2008.10.002
© 2008 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 23, Issue 1
, Pages 51-63
, February 2009
