Molecular pathology of thyroid cancer: diagnostic and clinical implications

There is now a reasonably good understanding of the key oncogenic events involved in the initiation and progression of thyroid cancer. Many of these are characteristic of certain tumor types, and their presence conveys diagnostic and prognostic information. It is not yet clear how this information will be applied to clinical practice. Based on preclinical evidence, mutations of genes encoding certain kinases may also predict response to specific tyrosine kinase inhibitors, although this has not yet been explored systematically in clinical trials.

Key words: thyroid cancer, pathogenesis, oncogene, RET, BRAF, RAS, molecular diagnostics, PTEN, PI3 kinase