Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 5 , Pages 813-829 , October 2008

Nutrition: its role in bone health

  • René Rizzoli, MD (Professor)

      Affiliations

    • Corresponding Author InformationTel.: +41 22 372 99 50; Fax: +41 22 382 99 73.

References 

  1. Rizzoli R, Bonjour JP, Ferrari SL. Osteoporosis, genetics and hormones. Journal of Molecular Endocrinology. 2001;26:79–94
  2. Ammann P, Bourrin S, Bonjour JP, et al. Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency. Journal of Bone and Mineral Research. 2000;15:683–690
  3. Chevalley T, Rizzoli R, Manen D, et al. Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells. Bone. 1998;23:103–109
  4. Rizzoli R, Bonjour JP. Dietary protein and bone health. Journal of Bone and Mineral Research. 2004;19:527–531
  5. Rizzoli R, Bonjour JP. Determinants of peak bone mass and mechanisms of bone loss. Osteoporosis International. 1999;9:S17–S23
  6. Bonjour JP, Theintz G, Buchs B, et al. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. The Journal of Clinical Endocrinology and Metabolism. 1991;73:555–563
  7. Theintz G, Buchs B, Rizzoli R, et al. Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. The Journal of Clinical Endocrinology and Metabolism. 1992;75:1060–1065
  8. Bonjour JP, Rizzoli R. Bone acquisition in adolescence. In:  Marcus R,  Feldman D,  Kelsey J editor. Osteoporosis. San Diego: Academic Press; 2001;p. 621–638
  9. Seeman E. The structural and biomechanical basis of the gain and loss of bone strength in women and men. Endocrinology and Metabolism Clinics of North America. 2003;32:25–38
  10. Bonjour JP, Carrie AL, Ferrari S, et al. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial. The Journal of Clinical Investigation. 1997;99:1287–1294
  11. Chevalley T, Bonjour JP, Ferrari S, et al. Skeletal site selectivity in the effects of calcium supplementation on areal bone mineral density gain: a randomized, double-blind, placebo-controlled trial in prepubertal boys. The Journal of Clinical Endocrinology and Metabolism. 2005;90:3342–3349
  12. Chevalley T, Bonjour JP, Ferrari S, et al. High-protein intake enhances the positive impact of physical activity on BMC in prepubertal boys. Journal of Bone and Mineral Research. 2008;23:131–142
  13. Johnston CC, Miller JZ, Slemenda CW, et al. Calcium supplementation and increases in bone mineral density in children. The New England Journal of Medicine. 1992;327:82–87
  14. Lee WT, Leung SS, Leung DM, et al. A randomized double-blind controlled calcium supplementation trial, and bone and height acquisition in children. The British Journal of Nutrition. 1995;74:125–139
  15. Lloyd T, Andon MB, Rollings N, et al. Calcium supplementation and bone mineral density in adolescent girls. The Journal of the American Medical Association. 1993;270:841–844
  16. Ferrari S, Rizzoli R, Manen D, et al. Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density: interaction with age, dietary calcium, and 3'-end region polymorphisms. Journal of Bone and Mineral Research. 1998;13:925–930
  17. Bonjour JP, Chevalley T, Ammann P, et al. Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study. Lancet. 2001;358:1208–1212
  18. Cadogan J, Eastell R, Jones N, et al. Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. BMJ. 1997;315:1255–1260
  19. Prentice A, Ginty F, Stear SJ, et al. Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys. Journal of Clinical Endocrinology and Metabolism. 2005;90:3153–3161
  20. Chevalley T, Rizzoli R, Hans D, et al. Interaction between calcium intake and menarcheal age on bone mass gain: an eight-year follow-up study from prepuberty to postmenarche. Journal of Clinical Endocrinology and Metabolism. 2005;90:44–51
  21. Winzenberg T, Shaw K, Fryer J, et al. Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials. BMJ. 2006;333:775–778
  22. Ferrari SL, Chevalley T, Bonjour JP, et al. Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?. Journal of Bone and Mineral Research. 2006;21:501–507
  23. Goulding A, Rockell JE, Black RE, et al. Children who avoid drinking cow's milk are at increased risk for prepubertal bone fractures. Journal of the American Dietetic Association. 2004;104:250–253
  24. Ma D, Jones G. The association between bone mineral density, metacarpal morphometry, and upper limb fractures in children: a population-based case-control study. Journal of Clinical Endocrinology and Metabolism. 2003;88:1486–1491
  25. Bonjour JP, Ammann P, Chevalley T, et al. Protein intake and bone growth. Canadian Journal of Applied Physiology. 2001;(26 Suppl):S153–S166
  26. Chevalley T, Ferrari S, Hans D, et al. Protein intake modulates the effect of calcium supplementation on bone mass gain in prepubertal boys. Journal of Bone and Mineral Research. 2002;17(Suppl. 1):S172
  27. Clavien H, Theintz G, Rizzoli R, et al. Does puberty alter dietary habits in adolescents living in a western society?. The Journal of Adolescent Health. 1996;19:68–75
  28. Alexy U, Remer T, Manz F, et al. Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children. The American Journal of Clinical Nutrition. 2005;82:1107–1114
  29. Kelly O, Cusack S, Cashman KD. The effect of bovine whey protein on ectopic bone formation in young growing rats. The British Journal of Nutrition. 2003;90:557–564
  30. Kruger MC, Plimmer GG, Schollum LM, et al. The effect of whey acidic protein fractions on bone loss in the ovariectomised rat. The British Journal of Nutrition. 2005;94:244–252
  31. Bounds W, Skinner J, Carruth BR, et al. The relationship of dietary and lifestyle factors to bone mineral indexes in children. Journal of the American Dietetic Association. 2005;105:735–741
  32. Chan GM, Hoffman K, McMurry M. Effects of dairy products on bone and body composition in pubertal girls. The Journal of Pediatrics. 1995;126:551–556
  33. Black RE, Williams SM, Jones IE, et al. Children who avoid drinking cow milk have low dietary calcium intakes and poor bone health. The American Journal of Clinical Nutrition. 2002;76:675–680
  34. Henderson RC, Hayes PR. Bone mineralization in children and adolescents with a milk allergy. Bone and Mineral. 1994;27:1–12
  35. Hidvegi E, Arato A, Cserhati E, et al. Slight decrease in bone mineralization in cow milk-sensitive children. Journal of Pediatric Gastroenterology and Nutrition. 2003;36:44–49
  36. Infante D, Tormo R. Risk of inadequate bone mineralization in diseases involving long-term suppression of dairy products. Journal of Pediatric Gastroenterology and Nutrition. 2000;30:310–313
  37. Jensen VB, Jorgensen IM, Rasmussen KB, et al. Bone mineral status in children with cow milk allergy. Pediatric Allergy and Immunology. 2004;15:562–565
  38. Rockell JE, Williams SM, Taylor RW, et al. Two-year changes in bone and body composition in young children with a history of prolonged milk avoidance. Osteoporosis International. 2005;16:1016–1023
  39. Opotowsky AR, Bilezikian JP. Racial differences in the effect of early milk consumption on peak and postmenopausal bone mineral density. Journal of Bone and Mineral Research. 2003;18:1978–1988
  40. Teegarden D, Lyle RM, Proulx WR, et al. Previous milk consumption is associated with greater bone density in young women. The American Journal of Clinical Nutrition. 1999;69:1014–1017
  41. Matkovic V, Landoll JD, Badenhop-Stevens NE, et al. Nutrition influences skeletal development from childhood to adulthood: a study of hip, spine, and forearm in adolescent females. The Journal of Nutrition. 2004;134:701S–705S
  42. Wiley AS. Does milk make children grow? Relationships between milk consumption and height in NHANES 1999–2002. American Journal of Human Biology. 2005;17:425–441
  43. Orr J. Milk consumption and the growth of school-children. Lancet. 1928;1:202–203
  44. Leighton G, Clark M. Milk consumption and the growth of school-children. Lancet. 1929;1:40–43
  45. Cheng S, Lyytikainen A, Kroger H, et al. Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10–12-y-old girls: a 2-y randomized trial. The American Journal of Clinical Nutrition. 2005;82:1115–1126quiz 1147–1118
  46. Baker IA, Elwood PC, Hughes J, et al. A randomised controlled trial of the effect of the provision of free school milk on the growth of children. Journal of Epidemiology and Community Health. 1980;34:31–34
  47. Du X, Zhu K, Trube A, et al. Effects of school-milk intervention on growth and bone mineral accretion in Chinese girls aged 10–12 years: accounting for cluster randomisation. The British Journal of Nutrition. 2005;94:1038–1039
  48. Du X, Zhu K, Trube A, et al. School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10–12 years in Beijing. The British Journal of Nutrition. 2004;92:159–168
  49. Lau EM, Lynn H, Chan YH, et al. Benefits of milk powder supplementation on bone accretion in Chinese children. Osteoporosis International. 2004;15:654–658
  50. Merrilees MJ, Smart EJ, Gilchrist NL, et al. Effects of diary food supplements on bone mineral density in teenage girls. European Journal of Nutrition. 2000;39:256–262
  51. Volek JS, Gomez AL, Scheett TP, et al. Increasing fluid milk favorably affects bone mineral density responses to resistance training in adolescent boys. Journal of the American Dietetic Association. 2003;103:1353–1356
  52. Zhu K, Du X, Cowell CT, et al. Effects of school milk intervention on cortical bone accretion and indicators relevant to bone metabolism in Chinese girls aged 10–12 y in Beijing. The American Journal of Clinical Nutrition. 2005;81:1168–1175
  53. Zhu K, Zhang Q, Foo LH, et al. Growth, bone mass, and vitamin D status of Chinese adolescent girls 3 y after withdrawal of milk supplementation. The American Journal of Clinical Nutrition. 2006;83:714–721
  54. Fordtran JS, Walsh JH. Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. The Journal of Clinical Investigation. 1973;52:645–657
  55. Hernandez CJ, Gupta A, Keaveny TM. A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. Journal of Bone and Mineral Research. 2006;21:1248–1255
  56. Boonen S, Rizzoli R, Meunier PJ, et al. The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis: a consensus report. Osteoporosis International. 2004;15:511–519
  57. Chevalley T, Rizzoli R, Nydegger V, et al. Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D-replete elderly patients. Osteoporosis International. 1994;4:245–252
  58. Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. The New England Journal of Medicine. 1997;337:670–676
  59. Shea B, Wells G, Cranney A, et al. Calcium supplementation on bone loss in postmenopausal women. Cochrane Database of Systematic Reviews. 2003;CD004526
  60. Burckhardt P. The effect of the alkali load of mineral water on bone metabolism: interventional studies. The Journal of Nutrition. 2008;138:435S–437S
  61. Dvorak MM, Siddiqua A, Ward DT, et al. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proceedings of the National Academy of Sciences of the United States of America. 2004;101:5140–5145
  62. Yamaguchi T, Chattopadhyay N, Kifor O, et al. Mouse osteoblastic cell line (MC3T3-E1) expresses extracellular calcium (Ca2+o)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells. Journal of Bone and Mineral Research. 1998;13:1530–1538
  63. Yamauchi M, Yamaguchi T, Kaji H, et al. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. American Journal of Physiology. Endocrinology and Metabolism. 2005;288:E608–E616
  64. Dvorak MM, Chen TH, Orwoll B, et al. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007;148:3156–3163
  65. Ahlstrom M, Pekkinen M, Riehle U, et al. Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells. Bone. 2008;42:483–490
  66. Hauselmann HJ, Rizzoli R. A comprehensive review of treatments for postmenopausal osteoporosis. Osteoporosis International. 2003;14:2–12
  67. Cauley JA, Robbins J, Chen Z, et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. The Journal of the American Medical Association. 2003;290:1729–1738
  68. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. The New England Journal of Medicine. 1992;327:1637–1642
  69. Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet. 2005;365:1621–1628
  70. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. The New England Journal of Medicine. 2006;354:669–683
  71. Prince RL, Devine A, Dhaliwal SS, et al. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Archives of Internal Medicine. 2006;166:869–875
  72. Reid IR, Mason B, Horne A, et al. Randomized controlled trial of calcium in healthy older women. The American Journal of Medicine. 2006;119:777–785
  73. Boonen S, Lips P, Bouillon R, et al. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. Journal of Clinical Endocrinology and Metabolism. 2007;92:1415–1423
  74. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ. 2008;336:262–266
  75. Budek AZ, Hoppe C, Ingstrup H, et al. Dietary protein intake and bone mineral content in adolescents-The Copenhagen Cohort Study. Osteoporosis International. 2007;18:1661–1667
  76. Cooper C, Atkinson EJ, Hensrud DD, et al. Dietary protein intake and bone mass in women. Calcified Tissue International. 1996;58:320–325
  77. Hirota T, Nara M, Ohguri M, et al. Effect of diet and lifestyle on bone mass in Asian young women. The American Journal of Clinical Nutrition. 1992;55:1168–1173
  78. Chiu JF, Lan SJ, Yang CY, et al. Long-term vegetarian diet and bone mineral density in postmenopausal Taiwanese women. Calcified Tissue International. 1997;60:245–249
  79. Devine A, Dick IM, Islam AF, et al. Protein consumption is an important predictor of lower limb bone mass in elderly women. The American Journal of Clinical Nutrition. 2005;81:1423–1428
  80. Geinoz G, Rapin CH, Rizzoli R, et al. Relationship between bone mineral density and dietary intakes in the elderly. Osteoporosis International. 1993;3:242–248
  81. Ho SC, Woo J, Lam S, et al. Soy protein consumption and bone mass in early postmenopausal Chinese women. Osteoporosis International. 2003;14:835–842
  82. Ilich JZ, Brownbill RA, Tamborini L. Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. European Journal of Clinical Nutrition. 2003;57:554–565
  83. Kerstetter JE, Looker AC, Insogna KL. Low dietary protein and low bone density. Calcified Tissue International. 2000;66:313
  84. Lau EM, Kwok T, Woo J, et al. Bone mineral density in Chinese elderly female vegetarians, vegans, lacto-vegetarians and omnivores. European Journal of Clinical Nutrition. 1998;52:60–64
  85. Michaelsson K, Holmberg L, Mallmin H, et al. Diet, bone mass, and osteocalcin: a cross-sectional study. Calcified Tissue International. 1995;57:86–93
  86. Sellmeyer DE, Stone KL, Sebastian A, et al. A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. The American Journal of Clinical Nutrition. 2001;73:118–122
  87. Teegarden D, Lyle RM, McCabe GP, et al. Dietary calcium, protein, and phosphorus are related to bone mineral density and content in young women. The American Journal of Clinical Nutrition. 1998;68:749–754
  88. Thorpe M, Mojtahedi MC, Chapman-Novakofski K, et al. A positive association of lumbar spine bone mineral density with dietary protein is suppressed by a negative association with protein sulfur. The Journal of Nutrition. 2008;138:80–85
  89. Tylavsky FA, Anderson JJ. Dietary factors in bone health of elderly lactoovovegetarian and omnivorous women. The American Journal of Clinical Nutrition. 1988;48:842–849
  90. Coin A, Perissinotto E, Enzi G, et al. Predictors of low bone mineral density in the elderly: the role of dietary intake, nutritional status and sarcopenia. European Journal of Clinical Nutrition. 2007;
  91. Orwoll ES, Weigel RM, Oviatt SK, et al. Serum protein concentrations and bone mineral content in aging normal men. The American Journal of Clinical Nutrition. 1987;46:614–621
  92. Whiting SJ, Boyle JL, Thompson A, et al. Dietary protein, phosphorus and potassium are beneficial to bone mineral density in adult men consuming adequate dietary calcium. Journal of the American College of Nutrition. 2002;21:402–409
  93. Hannan MT, Tucker KL, Dawson-Hughes B, et al. Effect of dietary protein on bone loss in elderly men and women: the Framingham osteoporosis Study. Journal of Bone and Mineral Research. 2000;15:2504–2512
  94. Dawson-Hughes B, Harris SS. Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. The American Journal of Clinical Nutrition. 2002;75:773–779
  95. Dawson-Hughes B. Interaction of dietary calcium and protein in bone health in humans. The Journal of Nutrition. 2003;133:852S–854S
  96. Metz JA, Anderson JJ, Gallagher PN. Intakes of calcium, phosphorus, and protein, and physical-activity level are related to radial bone mass in young adult women. The American Journal of Clinical Nutrition. 1993;58:537–542
  97. Abelow BJ, Holford TR, Insogna KL. Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcified Tissue International. 1992;50:14–18
  98. Frassetto LA, Todd KM, Morris RC, et al. Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2000;55:M585–M592
  99. Feskanich D, Willett WC, Stampfer MJ, et al. Protein consumption and bone fractures in women. American Journal of Epidemiology. 1996;143:472–479
  100. Munger RG, Cerhan JR, Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. The American Journal of Clinical Nutrition. 1999;69:147–152
  101. Wengreen HJ, Munger RG, West NA, et al. Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utah. Journal of Bone and Mineral Research. 2004;19:537–545
  102. Meyer HE, Pedersen JI, Loken EB, et al. Dietary factors and the incidence of hip fracture in middle-aged Norwegians. A prospective study. American Journal of Epidemiology. 1997;145:117–123
  103. Lemann J. Relationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review. Nephron. 1999;81(Suppl. 1):18–25
  104. Heaney RP, Recker RR. Effects of nitrogen, phosphorus, and caffeine on calcium balance in women. The Journal of Laboratory and Clinical Medicine. 1982;99:46–55
  105. Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption. The American Journal of Clinical Nutrition. 1998;68:859–865
  106. Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. The American Journal of Clinical Nutrition. 2003;78:584S–592S
  107. Kerstetter JE, Mitnick ME, Gundberg CM, et al. Changes in bone turnover in young women consuming different levels of dietary protein. Journal of Clinical Endocrinology and Metabolism. 1999;84:1052–1055
  108. Roughead ZK, Johnson LK, Lykken GI, et al. Controlled high meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. The Journal of Nutrition. 2003;133:1020–1026
  109. Heaney RP. Protein intake and bone health: the influence of belief systems on the conduct of nutritional science. The American Journal of Clinical Nutrition. 2001;73:5–6
  110. New SA. Nutrition Society Medal lecture. The role of the skeleton in acid-base homeostasis. The Proceedings of the Nutrition Society. 2002;61:151–164
  111. Lutz J. Calcium balance and acid-base status of women as affected by increased protein intake and by sodium bicarbonate ingestion. The American Journal of Clinical Nutrition. 1984;39:281–288
  112. Sebastian A, Harris ST, Ottaway JH, et al. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. The New England Journal of Medicine. 1994;330:1776–1781
  113. New SA, Bolton-Smith C, Grubb DA, et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. The American Journal of Clinical Nutrition. 1997;65:1831–1839
  114. New SA. Intake of fruit and vegetables: implications for bone health. Proceedings of the Nutrition Society. 2003;62:889–899
  115. Muhlbauer RC, Li F. Effect of vegetables on bone metabolism. Nature. 1999;401:343–344
  116. Muhlbauer RC, Lozano A, Reinli A. Onion and a mixture of vegetables, salads, and herbs affect bone resorption in the rat by a mechanism independent of their base excess. Journal of Bone and Mineral Research. 2002;17:1230–1236
  117. Lemann J, Gray RW, Pleuss JA. Potassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. Kidney International. 1989;35:688–695
  118. Sakhaee K, Nicar M, Hill K, et al. Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. Kidney International. 1983;24:348–352
  119. Niu T, Rosen CJ. The insulin-like growth factor-I gene and osteoporosis: a critical appraisal. Gene. 2005;361:38–56
  120. Caverzasio J, Montessuit C, Bonjour JP. Stimulatory effect of insulin-like growth factor-1 on renal Pi transport and plasma 1,25-dihydroxyvitamin D3. Endocrinology. 1990;127:453–459
  121. Palmer G, Bonjour JP, Caverzasio J. Stimulation of inorganic phosphate transport by insulin-like growth factor I and vanadate in opossum kidney cells is mediated by distinct protein tyrosine phosphorylation processes. Endocrinology. 1996;137:4699–4705
  122. Palmer G, Bonjour JP, Caverzasio J. Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I. Endocrinology. 1997;138:5202–5209
  123. Thissen JP, Ketelslegers JM, Underwood LE. Nutritional regulation of the insulin-like growth factors. Endocrine Reviews. 1994;15:80–101
  124. Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C concentrations in humans. The Journal of Clinical Investigation. 1983;71:175–182
  125. Thissen JP, Davenport ML, Pucilowska JB, et al. Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats. The American Journal Of Physiology. 1992;262:E406–E411
  126. Bourrin S, Ammann P, Bonjour JP, et al. Dietary protein restriction lowers plasma insulin-like growth factor I (IGF-I), impairs cortical bone formation, and induces osteoblastic resistance to IGF-I in adult female rats. Endocrinology. 2000;141:3149–3155
  127. Bourrin S, Toromanoff A, Ammann P, et al. Dietary protein deficiency induces osteoporosis in aged male rats. Journal of Bone and Mineral Research. 2000;15:1555–1563
  128. Ammann P, Laib A, Bonjour JP, et al. Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet. Journal of Bone and Mineral Research. 2002;17:1264–1272
  129. Conigrave AD, Hampson DR. Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors. Trends in Endocrinology and Metabolism. 2006;17:398–407
  130. Conigrave AD, Mun HC, Delbridge L, et al. L-amino acids regulate parathyroid hormone secretion. The Journal of Biological Chemistry. 2004;279:38151–38159
  131. Conigrave AD, Mun HC, Lok HC. Aromatic L-amino acids activate the calcium-sensing receptor. The Journal of Nutrition. 2007;137:1524S–1527S[discussion: 1548S]
  132. Dawson-Hughes B, Harris SS, Rasmussen HM, et al. Comparative effects of oral aromatic and branched-chain amino acids on urine calcium excretion in humans. Osteoporosis International. 2007;18:955–961
  133. Ammann P, Gabay C, Palmer G, et al. Tumor necrosis factor alpha but not interleukine-1 is involved in protein undernutrition-induced bone resorption. Journal of Bone and Mineral Research. 2002;17(Suppl. 1):S205
  134. Ammann P, Garcia I, Bonjour JP, et al. Tumor necrosis factor-a (TNF) plays a prominent role in protein undernutrition-induced bone resorption. Journal of Bone and Mineral Research. 2001;16(Suppl. 1):S147
  135. Ammann P, Kream B, Rosen C, et al. Overexpression of osteoblast IGF-I blunts the deleterious effects of IOw protein intake on bone strength. Journal of Bone and Mineral Research. 2007;22(Suppl. 1):S464
  136. Delmi M, Rapin CH, Bengoa JM, et al. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet. 1990;335:1013–1016
  137. Tkatch L, Rapin CH, Rizzoli R, et al. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. Journal of the American College of Nutrition. 1992;11:519–525
  138. Schurch MA, Rizzoli R, Slosman D, et al. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine. 1998;128:801–809
  139. Hampson G, Martin FC, Moffat K, et al. Effects of dietary improvement on bone metabolism in elderly underweight women with osteoporosis: a randomised controlled trial. Osteoporosis International. 2003;14:750–756
  140. Auernhammer CJ, Strasburger CJ. Effects of growth hormone and insulin-like growth factor I on the immune system. European Journal of Endocrinology. 1995;133:635–645
  141. Rodondi A, Ammann P & Rizzoli R. Effect of zinc supplements on the response to essential amino acid-whey protein supplements in frail elderly. Journal of the American Geriatrics Society, in press.
  142. Elefteriou F, Benson MD, Sowa H, et al. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metabolism. 2006;4:441–451
  143. Yang X, Matsuda K, Bialek P, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004;117:387–398
  144. Harding HP, Zhang Y, Zeng H, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell. 2003;11:619–633

PII: S1521-690X(08)00091-2

doi: 10.1016/j.beem.2008.08.005

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 5 , Pages 813-829 , October 2008