Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 5 , Pages 813-829, October 2008

Nutrition: its role in bone health

  • René Rizzoli, MD (Professor)

      Affiliations

    • Corresponding Author InformationTel.: +41 22 372 99 50; Fax: +41 22 382 99 73.

Division of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, CH - 1211 Geneva 14, Switzerland

At a given age, bone mass is determined by the amount of bone accumulated at the end of skeletal growth (the so-called peak bone mass), and by the amount of bone lost subsequently. Nutritional intake is an environmental factor that influences both bone capital accumulation, which is fully achieved by the end of the second decade of life, and bone loss, which occurs during the second half of existence. Nutrients may act directly by modifying bone turnover, or indirectly via changes in calciotropic hormone secretion. The study of the association between nutrition and a bone phenotypic expression may provide inconsistent results, in part because of the low accuracy and reproducibility of the various tools used to assess dietary intakes. Sufficient dietary calcium and protein are necessary for bone health during growth as well as in the elderly.

Key words: protein, calcium, fracture, bone mineral density, growth, osteoporosis

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PII: S1521-690X(08)00091-2

doi:10.1016/j.beem.2008.08.005

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 5 , Pages 813-829, October 2008