Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 3 , Pages 525-537 , June 2008

Optimal use of growth hormone therapy for maximizing adult height in children born small for gestational age

  • Dominique Simon, MD (Doctor)

      Affiliations

    • Corresponding Author InformationCorresponding author. Endocrinologie Diabétologie Pédiatrique, Hôpital Robert Debré, 48 boulevard Sérurier, 75935 Paris cedex 19, France. Tel.: +33 1 40 03 36 34; Fax: +33 1 40 03 24 29.
  • ,
  • Juliane Léger, MD (Professor)
  • ,
  • Jean-Claude Carel, MD (Professor)

References 

  1. Karlberg J, Albertsson-Wikland K. Growth in full-term small for gestational age infants: from birth to final height. Pediatric Research. 1995;38:733–739
  2. Léger J, Lévy-Marchal C, Bloch J, et al. Reduced final height and indications for early development of insulin resistance in a 20 year old population born with intra uterine growth retardation. BMJ (Clinical Research ed.). 1997;315:341–347
  3. Léger J, Limoni C, Czernichow P. Prediction factors in the determination of final height in subjects born small for gestational age. Pediatric Research. 1998;43:808–812
  4. Hokken-Koelega ACS, De Ridder MA, Lemmen RJ, et al. Children born small for gestational age: do they catch up?. Pediatric Research. 1995;38:267–271
  5. Léger J, Noel M, Limal JM, et al. Growth factors and intrauterine growth retardation: serum GH, IGF-I, and IGFBP3 levels in children with intrauterine growth retardation as compared with normal controls. Prospective study from birth to 2 years of age. Pediatric Research. 1996;40:94–100
  6. Chellakooty M, Juul A, Boisen A, et al. A prospective study of serum insulin-like growth factor I and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding. The Journal of Clinical Endocrinology and Metabolism. 2006;91:820–826
  7. de Waal WJ, Hokken-Kolega ACS, Stijnen TH, et al. Endogenous and stimulated GH secretion, urinary GH excretion, and plasma IGF-I and IGFII levels in prepubertal children with short stature after intrauterine growth retardation. Clinical Endocrinology. 1994;41:621–630
  8. Verkauskiene R, Jaquet D, Deghmoun S, et al. Smallness for gestational age is associated with persistent change in insulin-like growth factor I and the ratio of IGF-I/IGF-binding protein-3 in adulthood. The Journal of Clinical Endocrinology and Metabolism. 2005;90:5672–5676
  9. Albertsson-Wikland K, Karlberg J. Natural growth in children born small for gestational age with and without catch-up growth. Acta Paediatrica (Oslo, Norway: 1992). Supplement. 1994;399:64–70
  10. Chaussain JL, Colle M, Ducret JP. Adult height in children with prepubertal short stature secondary to intrauterine growth retardation. Acta Paediatrica (Oslo, Norway: 1992). Supplement. 1994;399:72–73
  11. Fjellestad-Paulsen A, Czernichow P, Brauner R, et al. Three-year data from a comparative study with recombinant human growth hormone in the treatment of short stature in young children with intrauterine growth retardation. Acta Paediatrica (Oslo, Norway: 1992). Supplement. 1998;87:511–517
  12. de Zegher F, Maes M, Gargosky SE, et al. High-dose growth hormone treatment of short children born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. 1996;81:1887–1892
  13. de Zegher F, Butenandt O, Chatelain P, et al. Growth hormone treatment of short children born small for gestational age: reappraisal of the rate of bone maturation over 2 years and metanalysis of height gain over 4 years. Acta Paediatrica (Oslo, Norway: 1992). Supplement. 1997;423:207–212
  14. de Zegher F, Albertsson-Wikland K, Wollmann HA, et al. Growth hormone treatment of short children born small for gestational age: growth responses with continuous and discontinuous regimens over 6 years. The Journal of Clinical Endocrinology and Metabolism. 2000;85:2816–2821
  15. de Zegher F, Du Caju MV, Heinrichs C, et al. Early, discontinuous, high dose growth hormone treatment to normalize height and weight of short children born small for gestational age: results over 6 years. The Journal of Clinical Endocrinology and Metabolism. 1999;84:1558–1561
  16. Simon D, Léger J, Fjellestad-Paulsen A, et al., SGA Study Group  Intermittent recombinant growth hormone treatment in short children born small for gestational age: four-year results of a randomized trial of two different treatment regimens. Hormone Research. 2006;66:118–123
  17. Czernichow P. Treatment with growth hormone in short children born with intrauterine growth retardation. Endocrine. 2001;15:39–42
  18. Fjellestad-Paulsen A, Simon D, Czernichow P. Short children born small for gestational age and treated with growth hormone for three years have an important catch-down five years after discontinuation of treatment. The Journal of Clinical Endocrinology and Metabolism. 2004;89:1234–1239
  19. van Pareren Y, Mulder P, Houdijk M, et al. Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial. The Journal of Clinical Endocrinology and Metabolism. 2003;88:3584–3590
  20. Bannink EM, van Doorn J, Mulder PG, et al. Free/dissociable insulin-like growth factor (IGF)-I, not total IGF-I, correlates with growth response during growth hormone treatment in children born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. 2007;92:2992–3000
  21. Dahlgren J, Wikland KA, Swedish Study Group for Growth Hormone Treatment . Final height in short children born small for gestational age treated with growth hormone. Pediatric Research. 2005;57:216–222
  22. Boonstra V, van Pareren Y, Mulder P, et al. Puberty in growth hormone-treated children born small for gestational age (SGA). The Journal of Clinical Endocrinology and Metabolism. 2003;88:5753–5758
  23. Carel JC, Chatelain P, Rochiccioli P, et al. Improvement in adult height after growth hormone treatment in adolescents with short stature born small for gestational age: results of a randomized controlled study. The Journal of Clinical Endocrinology and Metabolism. 2003;88:1587–1593
  24. Coutant R, Carel JC, Letrait M, et al. Short stature associated with intrauterine growth retardation: final height of untreated and growth hormone-treated children. The Journal of Clinical Endocrinology and Metabolism. 1998;83:1070–1074
  25. Zucchini S, Cacciari E, Balsamo A, et al. Final height of short subjects of low birth weight with and without growth hormone treatment. Archives of Disease in Childhood. 2001;84:340–343
  26. Ranke MB, Lindberg A, Cowell CT, et al. Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database). The Journal of Clinical Endocrinology and Metabolism. 2003;88:125–131
  27. Sas T, de Waal W, Mulder P, et al. Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. The Journal of Clinical Endocrinology and Metabolism. 1999;84:3064–3070
  28. de Ridder MA, Stijnen T, Hokken-Koelega AC. Prediction model for adult height of SGA children at start of growth hormone treatment. The Journal of Clinical Endocrinology and Metabolism. 2008;93:477–483
  29. de Zegher F, Hokken-Koelega A. Growth hormone therapy for children born small for gestational age: height gain is less dose dependent over the long term than over the short term. Pediatrics. 2005;115:458–462
  30. Clayton PE, Cianfarani S, Czernichow P, et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. The Journal of Clinical Endocrinology and Metabolism. 2007;92:804–810
  31. Azcona C, Albanese A, Bareille P, et al. Growth hormone treatment in growth hormone-sufficient and -insufficient children with intrauterine growth retardation/Russell-Silver syndrome. Hormone Research. 1998;50:22–27
  32. de Zegher F, Ong K, van Helvoirt M, et al. High-dose growth hormone (GH) treatment in non-GH-deficient children born small for gestational age induces growth responses related to pretreatment GH secretion and associated with a reversible decrease in insulin sensitivity. The Journal of Clinical Endocrinology and Metabolism. 2002;87:148–151
  33. Cohen P, Bright GM, Rogol AD, et al., American Norditropin Clinical Trials Group  Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. The Journal of Clinical Endocrinology and Metabolism. 2002;87:90–98
  34. Ali O, Cohen P. Insulin-like growth factors and their binding proteins in children born small for gestational age: implications for growth hormone therapy. Hormone Research. 2003;60(Suppl. 3):115–123
  35. Kamp GA, Mul D, Waelkens JJ, et al. A randomized controlled trial of three years growth hormone and gonadotropin-releasing hormone agonist treatment in children with idiopathic short stature and intrauterine growth retardation. The Journal of Clinical Endocrinology and Metabolism. 2001;86:2969–2975
  36. van Gool SA, Kamp GA, Visser-van Balen H, et al. Final height outcome after three years of growth hormone and gonadotropin-releasing hormone agonist treatment in short adolescents with relatively early puberty. The Journal of Clinical Endocrinology and Metabolism. 2007;92:1402–1408
  37. Argente J, Gracia R, Ibáñez L, et al. Improvement in growth after two years of growth hormone therapy in very young children born small for gestational age and without spontaneous catch-up growth: results of a multicenter, controlled, randomized, open clinical trial. The Journal of Clinical Endocrinology and Metabolism. 2007;92:3095–3101
  38. Cutfield WS, Lindberg A, Rapaport R, et al. Safety of growth hormone treatment in children born small for gestational age: the US trial and KIGS analysis. Hormone Research. 2006;65(Suppl. 3):153–159
  39. Chan JM, Stampfer MJ, Giovannucci E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science. 1998;279:563–566
  40. Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998;351:1393–1396
  41. Ma J, Pollak MN, Giovannucci E, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. Journal of the National Cancer Institute. 1999;91:620–625
  42. van Dijk M, Mulder P, Houdijk M, et al. High serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) during high-dose GH treatment in short children born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. 2006;91:1390–1396
  43. van Dijk M, Bannink EM, van Pareren YK, et al. Risk factors for diabetes mellitus type 2 and metabolic syndrome are comparable for previously growth hormone-treated young adults born small for gestational age (SGA) and untreated short SGA controls. The Journal of Clinical Endocrinology and Metabolism. 2007;92:160–165
  44. Léger J, Garel C, Fjellestad-Paulsen A, et al. Human growth hormone treatment of short-stature children born small for gestational age: effect on muscle and adipose tissue mass during a 3-year treatment period and after 1 year's withdrawal. The Journal of Clinical Endocrinology and Metabolism. 1998;83:3512–3516
  45. van Pareren Y, Mulder P, Houdijk M, et al. Effect of discontinuation of growth hormone treatment on risk factors for cardiovascular disease in adolescents born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. 2003;88:347–353
  46. Sas T, Mulder P, Aanstoot HJ, et al. Carbohydrate metabolism during long-term growth hormone treatment in children with short stature born small for gestational age. Clinical Endocrinology. 2001;54:243–251
  47. Sas T, Mulder P, Hokken-Koelega A. Body composition, blood pressure, and lipid metabolism before and during long-term growth hormone (GH) treatment in children with short stature born small for gestational age either with or without GH deficiency. The Journal of Clinical Endocrinology and Metabolism. 2000;85:3786–3792

PII: S1521-690X(08)00039-0

doi: 10.1016/j.beem.2008.03.003

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 3 , Pages 525-537 , June 2008