Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 3 , Pages 517-524 , June 2008

Individualization of growth hormone therapy

  • L.B. Johnston (Senior Lecturer and Honorary Consultant in Paediatric Endocrinology)

      Affiliations

    • Corresponding Author InformationCentre of Endocrinology, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK. Tel.: +44 207 882 6196; Fax: +44 207 7882 6197.

References 

  1. Karlberg J, Albertsson-Wikland K. Growth in full-term small-for-gestational-age infants: from birth to final height. Pediatric Research. 1995;38:733–739
  2. Hokken-Koelega AC, De Ridder MA, Lemmen RJ, et al. Children born small for gestational age: do they catch up?. Pediatric Research. 1995;38:267–271
  3. Johnston LB, Savage MO. Should recombinant human growth hormone therapy be used in short small for gestational age children?. Archives of Disease in Childhood. 2004;89:740–744
  4. Lee PA, Chernausek SD, Hokken-Koelega AC, et al. International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24–October 1, 2001. Pediatrics. 2003;111:1253–1261
  5. Clayton PE, Cianfarani S, Czernichow P, et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. The Journal of Clinical Endocrinology and Metabolism. 2007;92:804–810
  6. Rochiccioli P, Tauber M, Moisan V, et al. Investigation of growth hormone secretion in patients with intrauterine growth retardation. Acta Paediatrica Scandinavica. Supplement. 1989;349:42–46
  7. Boguszewski M, Albertsson-Wikland K, Aronsson S, et al. Growth hormone treatment of short children born small-for-gestational-age: the Nordic Multicentre Trial. Acta Paediatrica. 1998;87:257–263
  8. Job JC, Chaussain JL, Job B, et al. Follow-up of three years of treatment with growth hormone and of one post-treatment year, in children with severe growth retardation of intrauterine onset. Pediatric Research. 1996;39:354–359
  9. Van Pareren Y, Mulder P, Houdijk M, et al. Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: results of a randomized, double-blind, dose-response GH trial. The Journal of Clinical Endocrinology and Metabolism. 2003;88:3584–3590
  10. Zucchini S, Cacciari E, Balsamo A, et al. Final height of short subjects of low birth weight with and without growth hormone treatment. Archives of Disease in Childhood. 2001;84:340–343
  11. Carel JC, Chatelain P, Rochiccioli P, et al. Improvement in adult height after growth hormone treatment in adolescents with short stature born small for gestational age: results of a randomized controlled study. The Journal of Clinical Endocrinology and Metabolism. 2003;88:1587–1593
  12. Ranke MB, Lindberg A. Growth hormone treatment of short children born small for gestational age or with Silver-Russell syndrome: results from KIGS (Kabi International Growth Study), including the first report on final height. Acta Paediatrica. Supplementum. 1996;417:18–26
  13. Ranke MB, Lindberg A, Cowell CT, et al. Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database). The Journal of Clinical Endocrinology and Metabolism. 2003;88:125–131
  14. de Ridder MAJ, Stijnen T, Hokken-Koelega A. Prediction model for adult height of SGA children at start of growth hormone therapy. The Journal of Clinical Endocrinology and Metabolism. 2007;10:1210
  15. Dahlgren J, Wikland KA. Final height in short children born small for gestational age treated with growth hormone. Pediatric Research. 2005;57:216–222
  16. de Zegher F, Hokken-Koelega A. Growth hormone therapy for children born small for gestational age: height gain is less dose dependent over the long term than over the short term. Pediatrics. 2005;115:e458–e462
  17. Dos Santos C, Essioux L, Teinturier C, et al. A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Nature Genetics. 2004;36:720–724
  18. Tauber M, Ester W, Auriol F, et al. GH responsiveness in a large multinational cohort of SGA children with short stature (NESTEGG) is related to the exon 3 GHR polymorphism. Clinical Endocrinology (Oxford). 2007;67:457–461
  19. Binder G, Baur F, Schweizer R, et al. The d3-growth hormone receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short SGA children. The Journal of Clinical Endocrinology and Metabolism. 2006 Feb;91(2):659–664
  20. Carrascosa A, Audi L, Esteban C, et al. Growth hormone dose, but not exon 3-deleted/full-length growth hormone receptor polymorphism genotypes, influences growth response to two-year growth hormone therapy in short small-for-gestational-age children. The Journal of Clinical Endocrinology and Metabolism. 2008 Jan;93(1):147–153
  21. Sas TC, Gerver WJ, De Bruin R, et al. Body proportions during 6 years of GH treatment in children with short stature born small for gestational age participating in a randomised, double-blind, dose-response trial. Clinical Endocrinology (Oxford). 2000;53:675–681
  22. de Zegher F, Butenandt O, Chatelain P, et al. Growth hormone treatment of short children born small for gestational age: reappraisal of the rate of bone maturation over 2 years and metanalysis of height gain over 4 years. Acta Paediatrica. Supplementum. 1997;423:207–212
  23. Sas T, de Waal W, Mulder P, et al. Growth hormone treatment in children with short stature born small for gestational age: 5-year results of a randomized, double-blind, dose-response trial. The Journal of Clinical Endocrinology and Metabolism. 1999;84:3064–3070
  24. Boonstra V, Van Pareren Y, Mulder P, et al. Puberty in growth hormone-treated children born small for gestational age (SGA). The Journal of Clinical Endocrinology and Metabolism. 2003;88:5753–5758
  25. Darendeliler F, Ranke MB, Bakker B, et al. Bone age progression during the first year of growth hormone therapy in pre-pubertal children with idiopathic growth hormone deficiency, Turner syndrome or idiopathic short stature, and in short children born small for gestational age: analysis of data from KIGS (Pfizer International Growth Database). Hormone Research. 2005;63:40–47
  26. O'Keeffe MJ, O'Callaghan M, Williams GM, et al. Learning, cognitive, and attentional problems in adolescents born small for gestational age. Pediatrics. 2003;112:301–307
  27. Arends NJ, Boonstra VH, Hokken-Koelega AC. Head circumference and body proportions before and during growth hormone treatment in short children who were born small for gestational age. Pediatrics. 2004;114:683–690
  28. van Pareren YK, Duivenvoorden HJ, Slijper FS, et al. Intelligence and psychosocial functioning during long-term growth hormone therapy in children born small for gestational age. The Journal of Clinical Endocrinology and Metabolism. 2004;89:5295–5302
  29. van der Reijden-Lakeman IE, de Sonneville LM, Swaab-Barneveld HJ, et al. Evaluation of attention before and after 2 years of growth hormone treatment in intrauterine growth retarded children. Journal of Clinical and Experimental Neuropsychology. 1997;19:101–118
  30. van der Reijden-Lakeman I, Slijper FM, et al. Self-concept before and after two years of growth hormone treatment in intrauterine growth-retarded children. Hormone Research. 1996;46:88–94
  31. Visser-van Balen H, Geenen R, Moerbeek M, et al. Psychosocial functioning of adolescents with idiopathic short stature or persistent short stature born small for gestational age during three years of combined growth hormone and gonadotropin-releasing hormone agonist treatment. Hormone Research. 2005;64:77–87
  32. Lagrou K, Vanderfaeillie J, Froidecoeur C, et al. Effect of 2 years of high-dose growth hormone therapy on cognitive and psychosocial development in short children born small for gestational age. European Journal of Endocrinology. 2007;156:195–201

PII: S1521-690X(08)00036-5

doi: 10.1016/j.beem.2008.02.008

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 3 , Pages 517-524 , June 2008

Article Tools

* Image Usage & Resolution