Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 2 , Pages 317-329, April 2008

The benefits of early androgen blockade

  • Paul D. Maroni, MD (Assistant Professor, Department of Surgery (Urology))

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 303 724 2712; Fax: +1 303 724 2818.
    • ,
  • E. David Crawford, MD (Professor of Surgery, Chief of Urologic Oncology, Department of Radiation Oncology)

The University of Colorado at Denver and Health Sciences Center, Academic Office One Bldg, 12631 East 17th Ave, MS C319, Room L15-5602, Aurora, CO 80045, USA

Altering the effects of testosterone on prostate cancer cells by blocking androgen production or action is a critical part of treating this malignancy. The appropriate timing of androgen blockade for advanced prostate cancer is controversial. Despite many phase-III studies, gaps in clinical information still remain, and some questions are still not conclusively answered. This review concentrates on high-level evidence to address common clinical situations in advanced and metastatic prostate cancer. Additionally, the side-effects of androgen blockade have become increasingly visible and relevant.

Key words: prostate cancer, hormonal therapy

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PII: S1521-690X(08)00014-6

doi:10.1016/j.beem.2008.01.013

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 2 , Pages 317-329, April 2008

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