« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 2
, Pages 229-241
, April 2008
Intra-prostatic androgen levels during various androgen-blockade regimens
References
- . Testosterone and the prostate. In: Nieschlag E, Behre HM, Niechlag S editor. Testosterone. 3rd ed.. Cambridge University Press; 2004;p. 347–374
- . Studies on prostate cancer. Effect of castration, estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Research. 1941;1:293–297
- Combination therapy with flutamide and castration (LH-RH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival. Journal of Steroid Biochemistry. 1985;23:833–841
- . Treatment of newly diagnosed state D2 prostate cancer with leuprolide and flutamide or leuprolide alone, phase III, intergroup study 0036. The Journal of Steroid Biochemistry and Molecular Biology. 1990;37:961–963
- . Maximum androgen blockade in advanced prostate cancer: an overview of the randomised trials. Prostate Cancer Trialists' Collaborative Group. Lancet. 2000;355:1491–1498
- . Combined androgen blockade in prostate cancer: meta-analyses and associated issues. BJU International. 2001;87:806–813
- Gonadotropin-releasing hormone agonists in the treatment of prostate cancer. Endocrine Reviews. 2005;26:361–379
- Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. The New England Journal of Medicine. 1998;339:1036–1042
- Can combined androgen blockade provide long-term control or possible cure of localized prostate cancer?. Urology. 2002;60:115–119
- Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. The Journal of Clinical Endocrinology and Metabolism. 1992;74:505–508
- Science behind total androgen blockade: from gene to combination therapy. Clinical and Investigative Medicine. 1993;16:475–492
- . The influence of androgen eprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clinical Cancer Research. 2004;10:7121–7126
- Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies. British Journal of Cancer. 1999;80:930–934
- Hormonal predictors of prostate cancer: a meta-analysis. Journal of Clinical Oncology. 2000;18:847–853
- . Is low serum free testosterone a marker for high grade prostate cancer?. The Journal of Urology. 2000;163:824–827
- High-grade prostate cancer is associated with low serum testosterone levels. Prostate. 2001;47:52–58
- Pretreatment total testosterone level predicts pathological stage in patients with localized prostate cancer treated with radical prostatectomy. The Journal of Urology. 2003;169:1670–1675
- Testosterone as a predictor of pathological stage in clinically localized prostate cancer. The Journal of Urology. 2005;173:1935–1937
- Low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy: hypogonadism represents bad prognosis in prostate cancer. The Journal of Urology. 2005;174:2178–2180
- . On the prevention and therapy of prostate cancer by androgen administration. Cancer Research. 1999;59:4161–4164
- . Testosterone: an overview of biosynthesis, transport, metabolism and non-genomic actions. In: Nieschlag E, Behre HM, Niechlag S editor. Testosterone. 3rd ed.. Cambridge University Press; 2004;p. 1–37
- Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the Gleason score. The Journal of Urology. 2006;176:1387–1391
- Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study. Journal of Clinical Oncology. 2005;23:7546–7554
- Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer. Cancer Epidemiology, Biomarkers and Prevention. 2007;16:969–978
- Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5 alpha-reductase inhibitors. European Urology. 2007 Oct;52(4):1082–1087
- Genomic biomarkers, androgen pathway and prostate cancer. Pharmacogenomics. 2007;8:645–661
- The influence of finasteride on the development of prostate cancer. The New England Journal of Medicine. 2003;349:215–224
- Effects of long-term finasteride treatment on prostate cancer morphology and clinical outcome. Urology. 2005;66:930–934
- Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention Trial. Journal of the National Cancer Institute. 2007;99:1375–1383
- . Endogenous steroid levels in the human prostate from birth to old age: a comparison of normal and diseased tissues. The Journal of Endocrinology. 1978;78:7–19
- Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men. Journal of Steroid Biochemistry. 1989;32:695–698
- . Effects of castration compared with total androgen blockade on tissue dihydrotestosterone (DHT) concentration in benign prostatic hyperplasia (BPH). Urological Research. 1987;15:151–153
- The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score. The Journal of Urology. 2007;178:1282–1289
- In situ androgen producing enzymes in human prostate cancer. Endocrine-Relatated Cancer. 2005;12:101–107
- Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocrine-Relatated Cancer. 2006;13:169–180
- Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer. Journal of Clinical Pathology. 2007;(Epub ahead of print)
- Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Research. 2006;66:2815–2825
- High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer patients treated with radical prostatectomy. American Journal of Surgical Pathology. 2004;28:928–934
- Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy. The Journal of Urology. 2007;178:1290–1295
- . Treating prostate cancer: a rationale for targeting local oestrogens. Nature Reviews: Cancer. 2007;7:621–627
- The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens in patients with advanced prostate cancer. Journal of Endocrinological Investigation. 1988;11:693–696
- . Suppression of plasma androgens by the antiandrogen flutamide in prostatic cancer patients treated with Zoladex, a GnRH analogue. Clinical Endocrinology. 1990;32:329–339
- . Flutamide has no effect on adrenal androgen response to acute ACTH stimulation in patients with prostatic cancer. Prostate. 1990;17:219–225
- Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clinical Cancer Research. 2006;12:4072–4079
- . Steroid 5 alpha-reductase: two genes/ two enzymes. Annual Review of Biochemistry. 1994;63:25–61
- Differential alterations in 5 alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate. 2005;63:231–239
- Steroid 5 alpha-reductase isozymes I and II in recurrent prostate cancer. Clinical Cancer Research. 2005;11:4365–4371
- The effects of the dual 5 alpha-reductase inhibitor dutasteride on localized prostate cancer–results from a 4-month pre-radical prostatectomy study. Prostate. 2006;66:1674–1685
- . Androgen deprivation therapy for prostate cancer. JAMA: The Journal of the American Medical Association. 2005;294:238–244
- The androgen axis in recurrent prostate cancer. Clinical Cancer Research. 2004;10:440–448
- Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clinical Cancer Research. 2005;11:4653–4657
- Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer. Prostate Cancer Prostatic Diseases. 2007;10:301–306
- Secondary hormonal therapy for advanced prostate cancer. The Journal of Urology. 2006;175:27–34
- Adrenal androgen levels as predictors of outcome in prostate cancer patients treated with ketoconazole plus antiandrogen withdrawal: results from a cancer and leukemia group B study. Clinical Cancer Research. 2007;13:2030–2037
- Intra-prostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Research. 2007;67:5033–5041
PII: S1521-690X(08)00003-1
doi: 10.1016/j.beem.2008.01.002
© 2008 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 22, Issue 2
, Pages 229-241
, April 2008
