Intra-prostatic androgen levels during various androgen-blockade regimens

Androgens are heavily involved in the development of prostate cancer. This article reviews the scenario of the androgen environment and androgen metabolism in the prostate during androgen-deprivation therapy (ADT) in patients with prostate cancer. Ways of altering the intra-prostatic androgen milieu during various androgen-blockade regimens include surgical castration, luteinizing hormone-releasing hormone analogues to block androgen secretion by the testes, anti-androgens, and 5α-reductase inhibitors. The levels of androgen precursors in the blood are different under different ADT regimens, and the androgen levels in the prostate also vary according to the ADT used. This may affect the therapeutic effect of ADT. We therefore discuss the subject of prostatic androgen levels during various androgen-blockade regimens, and we describe the prospects for the future of ADT.

Key words: prostate cancer, testosterone, dihydrotestosterone, intra-prostatic androgen metabolism, androgen-deprivation therapy