« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 21, Issue 4
, Pages 535-553
, December 2007
Cannabinoid-1 receptor antagonists in type-2 diabetes
References
- . Guidelines on diabetes, prediabetes and cardiovascular diseases: executive summary. European Heart Journal. 2007;28:88–136
- . Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel iii) final report. Circulation. 2002;106:3143–3421
- Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation. 2004;110:2952–2967
- . Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–887
- . Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875–880
- . Current management strategies for coexisting diabetes mellitus and obesity. Drugs. 2003;63:1165–1184
- . Weight management for type-2 diabetes mellitus: global cardiovascular risk reduction. American Journal of Cardiology. 2007;99(supplementary):68B–79B
- . Clinical Practice Recommendations 2005. Diabetes Care. 2005;28(supplementary 1):S1–S79
- . Global Guideline for Type-2 Diabetes: recommendations for standard, comprehensive, and minimal care. Diabetic Medicine. 2006;23:579–593
- . Importance of weight management in type 2 diabetes: review with meta-analysis of clinical studies. Journal of the American College of Nutrition. 2003;22:331–339
- Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Circulation. 2006;113:898–918
- . The endocannabinoid system: a general view and latest additions. British Journal of Pharmacology. 2004;141:765–774
- Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 2004;47(supplementary 1):345–358
- The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine Reviews. 2006;27:73–100
- . The molecular logic of endocannabinoid signalling. Nature Reviews. Neuroscience. 2003;4:873–884
- . The endocannabinoid system and its therapeutic exploitation. Nature Reviews. Drug Discovery. 2004;3:771–784
- . Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions. British Journal of Pharmacology. 2007;151:427–440
- The endocannabinoid system and rimonabant: a new drug with a novel mechanism of action involving cannabinoid CB1-receptor antagonism – or inverse agonism – as potential obesity treatment and other therapeutic use. Journal of Clinical Pharmacy and Therapeutics. 2007;32:209–231
- . Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks. Circulation. 2006;114:974–984
- . Endocannabinoid control of food intake and energy balance. Nature Neuroscience. 2005;8:585–589
- Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data. CNS Drug Reviews. 2006;12:91–99
- The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. The Journal of Clinical Investigation. 2003;112:423–431
- . Rimonabant: a cannabinoid receptor type 1 blocker for management of multiple cardiometabolic risk factors. Journal of the American College of Cardiology. 2006;47:1919–1926
- . Role of endocannabinoid system in regulating cardiovascular and metabolic risk factors. American Journal of Medicine. 2007;120(supplementary 3A):S19–S25
- . Effects of CB1 antagonist on the control of metabolic functions in obese type 2 diabetic patients. Diabetes & Metabolism. 2007;33:85–95
- . The chemistry of endocannabinoids. Journal of Endocrinological Investigation. 2006;29(supplementary to Ndeg 3):3–14
- . Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacology and Therapeutics. 1997;74:129–180
- . CB(1) and CB(2) receptor-mediated signaling: a focus on endocannabinoids. Prostaglandins Leukotrienes and Essential Fatty Acids. 2002;66:161–171
- . Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. The Journal of Pharmacological and Experimental Therapeutics. 2001;298:7–14
- . The cannabinoid system: A role in both the homeostatic and hedonic control of eating?. British Journal of Nutrition. 2003;90:729–734
- The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Molecular Pharmacology. 2003;63:908–914
- . Adiponectin: action, regulation and association to insulin sensitivity. Obesity Reviews. 2005;6:13–21
- . The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. Journal of Molecular Medicine. 2005;83:944–954
- Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. The Journal of Clinical Investigation. 2005;115:1298–1305
- Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. International Journal of Obesity and Related Metabolic Disorders. 2005;29:183–187
- Cannabinoid receptor regulates Ca(2+) signals and insulin secretion in pancreatic beta-cells. Cell Calcium. 2006;39:155–162
- Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. The Journal of Clinical Endocrinology and Metabolism. 2006;91:3171–3180
- . Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sciences. 2005;76:1307–1324
- Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behaviour and food aversions. Physiology & Behavior. 2007;91:383–388
- SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letters. 1994;350:240–244
- The synthesis and pharmacological evaluation of the cannabinoid antagonist SR141716A. Medicinal Chemistry Research. 1994;5:54–62
- . Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. Expert Opinion on Investigational Drugs. 2006;15:307–315
- . Rimonabant for overweight or obesity. Cochrane Database of Systematic Reviews. 2006;4:CD006162
- Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. Journal of Medicinal Chemistry. 2004;47:627–643
- Available from http://www.emea.eu.int/humandocs/Humans/EPAR/acomplia/acomplia.htm
- . Cannabinoid type 1 receptor antagonists (rimonabant) for smoking cessation. Cochrane Database of Systematic Reviews. 2007;(3):CD005353
- Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects. Molecular Pharmacology. 2007;71:1445–1456
- CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. International Journal of Obesity and Related Metabolic Disorders. 2004;28:640–648
- Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2003;284:R345–R353
- A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. The Journal of Neuroscience. 2002;22:9612–9617
- . Endocannabinoids promote hepatic lipogenesis and steatosis through CB1 receptors. Hepatology. 2005;42:959–961
- . Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes & Metabolism. 2000;26:98–106
- Approach to the pathogenesis and treatment of non-alcoholic steatohepatitis. Diabetes Care. 2004;27:2057–2066
- CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nature Medicine. 2006;12:671–676
- Identification of endocannabinoids and related compounds in human fat cells. Obesity. 2007;15:837–845
- The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB Journal. 2005;19:1567–1569
- . Endocannabinoids and the control of energy balance. Trends in Endocrinology and Metabolism. 2007;18:27–37
- Activation of the peripheral endocannabinoid system in human obesity. Diabetes. 2005;54:2838–2843
- Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes. 2006;55:3053–3060
- Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. International Journal of Obesity. 2007;31:692–699
- Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). International Journal of Obesity. 2005;29:755–759
- Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet. Hormone and Metabolic Research. 2007;39:395–397
- Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. The Journal of Clinical Endocrinology and Metabolism. 2007;92:2382–2386
- Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005;365:1389–1397
- Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients. RIO-North America: a randomized controlled trial. The Journal of the American Medical Association. 2006;295:761–775
- . Rimonabant in Obesity-Lipids Study Group. Effects on metabolic risk factors in overweight patients with dyslipidemia. The New England Journal of Medicne. 2005;353:2121–2134
- Rimonabant improves cardiometabolic risk factors in overweight/obese patients irrespective of treatment with statins: pooled data from the RIO program. (Abstract) Atherosclerosis. 2006;7(supplementary):329
- Ruilope LM, Després JP, Scheen A et al. Effect of rimonabant on blood pressure in overweight/obese patients with/without co-morbidities: analysis of pooled Rimonabant In Obesity (RIO) study results. Journal of Hypertension, (in press).
- Improvement of metabolic effects with rimonabant beyond the effect attributable to weight loss alone: pooled one year data from the RIO (Rimonabant In Obesity and Related Metabolic Disorders) program (Abstract). Journal of the American College of Cardiology. 2006;47(supplementary A):362-A
- Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet. 2006;368:1660–1672
- . Antidiabetic agents in subjects with mild dysglycaemia: prevention or early treatment of type 2 diabetes?. Diabetes & Metabolism. 2007;33:3–12
- Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2006;29:1963–1972
- Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis. Archives of Internal Medicine. 2004;164:395–404
- . Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet. 2007;369:71–77
- Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. The New England Journal of Medicine. 2003;348:383–393
- Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ (Clinical Research Ed). 2000;321:405–412
- SERENADE : Rimonabant monotherapy for treatment of multiple cardiometabolic risk factors in treatment-naïve patients with type 2 diabetes. (Abstract) Diabetic Medicine. 2006;23(supplementary 4):230
- . Fat in the liver and insulin resistance. Annals of Medicine. 2005;37:347–356
- . Diabetes, prediabetes, and cardiovascular risk: shifting the paradigm. American Journal of Medicine. 2005;118:939–947
- Intentional weight loss and mortality among overweight individuals with diabetes. Diabetes Care. 2000;23:1499–1504
- CRESCENDO Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes. Available from: http://www.clinicaltrials.gov/ct/show/NCT00263042?order = 2. [Accessed February 1, 2007].
- Van Gaal L, Pi-Sunyer X, Després JP et al. Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the RIO program. Diabetes Care (in press).
- Food and Drug Administration. Available from: http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4306b1-00-index.htm.
PII: S1521-690X(07)00082-6
doi: 10.1016/j.beem.2007.08.005
© 2007 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Endocrinology & Metabolism
Volume 21, Issue 4
, Pages 535-553
, December 2007
