Best Practice & Research Clinical Endocrinology & Metabolism
Volume 21, Issue 2 , Pages 223-236 , June 2007

Thyroid hormone transport by monocarboxylate transporters

  • Theo J. Visser, PhD (Professor)

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +31 10 463 5463; Fax: +31 10 463 5430.

References 

  1. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?. The Journal of Clinical Endocrinology and Metabolism. 2000;85:3975–3987
  2. Yen PM, Ando S, Feng X, et al. Thyroid hormone action at the cellular, genomic and target gene levels. Molecular and Cellular Endocrinology. 2006;246:121–127
  3. Dupre SM, Guissouma H, Flamant F, et al. Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology. 2004;145:2337–2345
  4. Davis PJ, Davis FB. Nongenomic actions of thyroid hormone on the heart. Thyroid. 2002;12:459–466
  5. Sen L, Sakaguchi Y, Cui G. G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes. American Journal of Physiology, Heart and Circulatory Physiology. 2002;283:H2119–H2129
  6. Hiroi Y, Kim HH, Ying H, et al. Rapid nongenomic actions of thyroid hormone. Proceedings of the National Academy of Sciences of the USA. 2006;103:14104–14109
  7. Scanlan TS, Suchland KL, Hart ME, et al. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nature Medicine. 2004;10:638–642
  8. Bianco AC, Salvatore D, Gereben B, et al. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocrine Reviews. 2002;23:38–89
  9. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. The Journal of Clinical Investigation. 2006;116:2571–2579
  10. Kester MH, Martinez de Mena R, Obregon MJ, et al. Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. The Journal of Clinical Endocrinology and Metabolism. 2004;89:3117–3128
  11. Baqui M, Botero D, Gereben B, et al. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. The Journal of Biological Chemistry. 2003;278:1206–1211
  12. Hennemann G, Docter R, Friesema EC, et al. Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocrine Reviews. 2001;22:451–476
  13. Friesema EC, Jansen J, Milici C, et al. Thyroid hormone transporters. Vitamins and Hormones. 2005;70:137–167
  14. Jansen J, Friesema EC, Milici C, et al. Thyroid hormone transporters in health and disease. Thyroid. 2005;15:757–768
  15. Friesema EC, Ganguly S, Abdalla A, et al. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. The Journal of Biological Chemistry. 2003;278:40128–40135
  16. Friesema EC, Kuiper GG, Jansen J, et al. Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Molecular Endocrinology (Baltimore, Md.). 2006;20:2761–2772
  17. Friesema EC, Jachtenberg JW, Jansen J, et al. Human monocarboxylate transporter 10 does transport thyroid hormone. Thyroid. 2006;16:913;(abstract)
  18. Halestrap AP, Meredith D. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflügers Archiv. 2004;447:619–628
  19. Garcia CK, Li X, Luna J, et al. cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994;23:500–503
  20. Rahman B, Schneider HP, Broer A, et al. Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1. Biochemistry. 1999;38:11577–11584
  21. Kirk P, Wilson MC, Heddle C, et al. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. The EMBO Journal. 2000;19:3896–3904
  22. Philp NJ, Wang D, Yoon H, et al. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Investigative Ophthalmology & Visual Science. 2003;44:1716–1721
  23. Wang Y, Tonouchi M, Miskovic D, et al. T3 increases lactate transport and the expression of MCT4, but not MCT1, in rat skeletal muscle. American Journal of Physiology, Endocrinology and Metabolism. 2003;285:E622–E628
  24. Enoki T, Yoshida Y, Lally J, et al. Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle. The Journal of Physiology. 2006;577:433–443
  25. Muramatsu T, Miyauchi T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histology and Histopathology. 2003;18:981–987
  26. Wilson MC, Meredith D, Fox JE, et al. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). The Journal of Biological Chemistry. 2005;280:27213–27221
  27. Manoharan C, Wilson MC, Sessions RB, et al. The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. Molecular Membrane Biology. 2006;23:486–498
  28. Poole RC, Halestrap AP. Interaction of the erythrocyte lactate transporter (monocarboxylate transporter 1) with an integral 70-kDa membrane glycoprotein of the immunoglobulin superfamily. The Journal of Biological Chemistry. 1997;272:14624–14628
  29. Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. The Biochemical Journal. 1999;343 Pt 2:281–299
  30. Bergersen LH. Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience. 2007;145:11–19
  31. Lafreniere RG, Carrel L, Willard HF. A novel transmembrane transporter encoded by the XPCT gene in Xq13.2. Human Molecular Genetics. 1994;3:1133–1139
  32. Rechsteiner M, Rogers SW. PEST sequences and regulation by proteolysis. Trends in Biochemical Sciences. 1996;21:267–271
  33. Suzuki S, Mori J, Kobayashi M, et al. Cell-specific expression of NADPH-dependent cytosolic 3,5,3′-triiodo-L-thyronine-binding protein (p38CTBP). European Journal of Endocrinology. 2003;148:259–268
  34. Mori J, Suzuki S, Kobayashi M, et al. Nicotinamide adenine dinucleotide phosphate-dependent cytosolic T(3) binding protein as a regulator for T(3)-mediated transactivation. Endocrinology. 2002;143:1538–1544
  35. Vie MP, Evrard C, Osty J, et al. Purification, molecular cloning, and functional expression of the human nicodinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein. Molecular Endocrinology (Baltimore, Md.). 1997;11:1728–1736
  36. Friesema EC, Jansen J, Heuer H, et al. Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8. Nature Clinical Practice, Endocrinology & Metabolism. 2006;2:512–523
  37. Alkemade A, Friesema EC, Kuiper GG, et al. Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary. European Journal of Endocrinology. 2006;154:491–500
  38. Prummel MF, Brokken LJ, Wiersinga WM. Ultra short-loop feedback control of thyrotropin secretion. Thyroid. 2004;14:825–829
  39. Heuer H, Maier MK, Iden S, et al. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology. 2005;146:1701–1706
  40. Alkemade A, Friesema EC, Unmehopa UA, et al. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. The Journal of Clinical Endocrinology and Metabolism. 2005;90:4322–4334
  41. Chan SY, Franklyn JA, Pemberton HN, et al. Monocarboxylate transporter 8 expression in the human placenta: the effects of severe intrauterine growth restriction. Journal of Endocrinology. 2006;189:465–471
  42. Friesema EC, Grueters A, Biebermann H, et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet. 2004;364:1435–1437
  43. Dumitrescu AM, Liao XH, Best TB, et al. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. American Journal of Human Genetics. 2004;74:168–175
  44. Sugiyama D, Kusuhara H, Taniguchi H, et al. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. The Journal of Biological Chemistry. 2003;278:43489–43495
  45. Tohyama K, Kusuhara H, Sugiyama Y. Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004;145:4384–4391
  46. Guadano-Ferraz A, Obregon MJ, St Germain DL, et al. The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proceedings of the National Academy of Sciences of the USA. 1997;94:10391–10396
  47. Tu HM, Legradi G, Bartha T, et al. Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology. 1999;140:784–790
  48. Jones SA, Thoemke KR, Anderson GW. The role of thyroid hormone in fetal and neonatal brain development. Current Opinion in Endocrinology Diabetes. 2005;10–16
  49. Dumitrescu AM, Liao XH, Weiss RE, et al. Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology. 2006;147:4036–4043
  50. Trajkovic M, Visser TJ, Mittag J, et al. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. The Journal of Clinical Investigation. 2007;117:627–635
  51. Zhou Y, Samson M, Osty J, et al. Evidence for a close link between the thyroid hormone transport system and the aromatic amino acid transport system T in erythrocytes. The Journal of Biological Chemistry. 1990;265:17000–17004
  52. Zhou Y, Samson M, Francon J, et al. Thyroid hormone concentrative uptake in rat erythrocytes. Involvement of the tryptophan transport system T in countertransport of tri-iodothyronine and aromatic amino acids. The Biochemical Journal. 1992;281(Pt 1):81–86
  53. Kemp HF, Taylor PM. Interactions between thyroid hormone and tryptophan transport in rat liver are modulated by thyroid status. The American Journal of Physiology. 1997;272:E809–E816
  54. Powell KA, Mitchell AM, Manley SW, et al. Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4)) in the human choriocarcinoma cell line, JAR. Journal of Endocrinology. 2000;167:487–492
  55. Ritchie JW, Collingwood CJ, Taylor PM. Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes. American Journal of Physiology, Endocrinology and Metabolism. 2001;280:E254–E259
  56. Kim DK, Kanai Y, Chairoungdua A, et al. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. The Journal of Biological Chemistry. 2001;276:17221–17228
  57. Kim DK, Kanai Y, Matsuo H, et al. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002;79:95–103
  58. Ramadan T, Camargo SM, Summa V, et al. Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway. Journal of Cellular Physiology. 2006;206:771–779
  59. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Role of thyroid hormone during early brain development. European Journal of Endocrinology. 2004;151(supplement 3):U25–U37

PII: S1521-690X(07)00030-9

doi: 10.1016/j.beem.2007.03.008

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 21, Issue 2 , Pages 223-236 , June 2007

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