Best Practice & Research Clinical Endocrinology & Metabolism
Volume 17, Issue 1 , Pages 165-175 , March 2003

The role of androgen therapy

  • Susan R Davis, MBBS, FRACP, PhD (Director Associate Professor)

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: The Jean Hailes Research Unit, 173 Carinish Road, Clayton, Vic. 3168, Australia. Tel.: +61-3-954-39612; Fax: +61-3-954-39609.
  • Henry G Burger, AO, MD, FRCP, FRACP, FCP (SA), FRANZCOG, FRCOG, FAA (Emeritus Director, Honorary Professorial Fellow)

Received 1 August 2002 ,Accepted 1 September 2002.

References 

  1. Davis SR, Burger HG. Androgens and the postmenopausal woman. Journal of Clinical Endocrinology and Metabolism. 1996;81:2759–2763
  2. Davis SR, Burger HG. The rationale for physiological testosterone replacement in women. Baillière's Clinical Endocrinology and Metabolism. 1998;12:391–405
  3. Davis SR. Androgen treatment in women. Medical Journal of Australia. 1999;170:545–549
  4. Yen SSC. In:  Yen SSC,  Jaffe RB,  Barbieri RL editor. Reproductive endocrinology. 4th edn. Philadelphia: WB Saunders Company; 1999;p. 479
  5. Burger HG. Androgen production in women. Fertility and Sterility. 2002;77(supplement 4):3–5
  6. Orentreich N, Brind JL, Rizer RL, et al.  Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. Journal of Clinical Endocrinology and Metabolism. 1984;59:551–555
  7. Burger HG, Dudley EC, Cui J, et al.  A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. Journal of Clinical Endocrinology and Metabolism. 2000;85:2832–2838
  8. Miller KK, Sesmilo G, Schiller A, et al.  Androgen insufficiency in women with hypopituitarism. Journal of Clinical Endocrinology and Metabolism. 2001;561–567
  9. Couzinet B, Meduri G, Lecce M, et al.  The post menopausal ovary is not a major androgen producing gland. Journal of Clinical Endocrinology and Metabolism. 2001;86:5060–5065
  10. Zumoff B, Strain GW, Miller LK, et al.  Twenty-four-hour plasma testosterone concentration declines with age in normal menopausal women. Journal of Clinical Endocrinology and Metabolism. 1995;80:1429–1430
  11. Mathur RS, Landgreve SC, Moody LO, et al.  The effect of estrogen treatment on plasma concentrations of steroid hormones, gonadotropins, prolactin and sex hormone-binding globulin in post-menopausal women. Maturitas. 1985;7:129–133
  12. Simon J, Klaiber E, Wiita B, et al.  Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion and endogenous androgen bioavailability in postmenopausal women. Menopause: The Journal of the American Menopause Society. 1999;6:138–146
  13. Davis SR, McCloud PI, Strauss BJG, et al.  Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas. 1995;21:227–236
  14. Studd JWW, Colins WP, Chakravarti S. Estradiol and testosterone implants in the treatment of psychosexual problems in postmenopausal women. British Journal of Obstetrics and Gynaecology. 1977;84:314–315
  15. Sherwin BB, Gelfand MM, Bredner W. Androgen enhances sexual motivation in females: a prospective, crossover study of sexual steroid administration in the surgical menopause. Psychosomatic Medicine. 1985;47:339–351
  16. Sherwin BB, Gelfand MM. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. American Journal of Obstetrics and Gynaecology. 1985;151:153–160
  17. Burger HG, Hailes J, Menelaus M, et al.  The management of persistent menopausal symptoms with estradiol-testosterone implants: clinical, lipid and hormonal results. Maturitas. 1984;6:351–358
  18. Burger HG, Hailes J, Nelson J, Menelaus M. Effect of combined implants of estradiol and testosterone on libido in postmenopausal women. British Medical Journal. 1987;294:936–937
  19. Shiften JL, Braunsten GD, Simon JA, et al.  Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. New England Journal of Medicine. 2000;343:682–688
  20. Arlt W, Callies F, Christoph , et al.  Dehydroepiandrosterone replacement in women with adrenal insufficiency. New England Journal of Medicine. 1999;341:1013–1020
  21. Raisz LG, Wiita B, Artis A, et al.  Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers on bone formation and resorption in postmenopausal women. Journal of Clinical Endocrinology and Metabolism. 1996;81:37–43
  22. Watts JB, Notelovitz M, Timmons MC, et al.  Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid–lipoprotein profiles in surgical menopause. Obstetrics and Gynecology. 1995;85:529–537
  23. Bachmann G, Bancroft J, Braunstein G, et al.  Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertillty and Sterility. 2002;77:660–665
  24. Kaplan HS, Owett T. The female androgen insufficiency syndrome. Journal of Sex and Marital Therapy. 1993;19:3–24
  25. Bachmann GA, Leiblum SR, Kemmann E, et al.  Sexual expression and its determinants in the post-menopausal woman. Maturitas. 1984;6:19–29
  26. Cutler WB, Garcia C-R, Huggins GR, Preti G. Sexual behavior and steroid levels among gynecologically premature premenopausal women. Fertility and Sterility. 1986;48:496–502
  27. Bancroft J, Sherwin B, Alexander GM, et al.  Oral contraceptives, androgens and the sexuality of young women. II. The role of androgens. Archives of Sexual Behavior. 1991;20:121–135
  28. Dennerstein L, Dudley EC, Hopper JL, et al.  A prospective population-based study of menopausal symptoms. Obstetrics and Gynecology. 2000;96:351–358
  29. Dennerstein L, Randolph J, Taffe J, et al.  Hormones, mood, sexuality and the menopausal transition. Fertility and Sterility. 2002;77(supplement 4):42–48
  30. Lobo RA. Androgens in postmenopausal women: production, possible role and replacement options. Obstetrical and Gynecological Survey. 2001;56:361–376
  31. Buckler HM, Robertson WR, Wu FCW. Which androgen replacement therapy for women?. Journal of Clinical Endocrinology and Metabolism. 1998;83:3920–3924
  32. Davis SR. Effects of tibolone on mood and libido. Menopause 2002; 9: 162–170.
  33. Worboys S, Kotsopoulos D, Teede H, et al.  Parental testosterone improves endothelium-dependent and independent vasodilation in postmenopausal women already receiving estrogen. Journal of Clinical Endocrinology and Metabolism. 2001;86:158–161
  34. Bernini GP, Sgro M, Moretti A, et al.  Endogenous androgens and carotid intimal-medial thickness in women. Journal of Clinical Endocrinology and Metabolism. 1999;84:2008–2012
  35. Zhou J, Ng S, Adesanya-Famuiyao , et al.  Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB Journal. 2000;14:1725–1730

PII: S1521-690X(02)00078-7

doi: 10.1016/S1521-690X(02)00078-7

Best Practice & Research Clinical Endocrinology & Metabolism
Volume 17, Issue 1 , Pages 165-175 , March 2003

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